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Content archived on 2024-05-30

Epigenetic modifications in glomerular nephropathy and renal aging

Objective

Here, we propose a program to identify the role of mTOR and autophagy dependent epigenetic
modifications during kidney aging. We have assembled a unique set of complementary mouse models including kidney specific and timely inducible autophagy and mTOR deficient mice. For the detailed molecular analysis of transgenic podocyte tissue, we have generated a double-labeled transgenic mouse model, where podocytes expressing green fluorescent protein are contrasted by other kidney cells expressing red fluorescent protein. Using this mouse model, we have pioneered a cell sorter based purification of glomerular podocytes from kidney single cell suspensions, which allows us to perform the first epigenetic analysis of aged and transgenically modified podocytes. mTOR and / or autophagy dependent gene expression signatures, histone modifications and chromatin-remodeling patterns associated with kidney aging in transgenic and wildtype mice will be identified. We recently showed that mTOR hyperactivation at early stages of diabetic nephropathy determines the progressive course of the disease. We now hypothesize that transient mTOR hyperactivation may induce epigenetic modifications representing the clinically observed, but still unresolved “metabolic memory” of diabetic nephropathy. In
summary, this project aims to elucidate fundamental biological mechanisms of kidney aging. This may ultimately aid in risk prediction and improved targeted medical interventions to promote healthy aging and to prevent chronic kidney diseases such as diabetic nephropathy.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-CIG
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

UNIVERSITAETSKLINIKUM FREIBURG
EU contribution
€ 100 000,00
Address
HUGSTETTER STRASSE 49
79106 Freiburg
Germany

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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