Epigenetic modifications in glomerular nephropathy and renal aging

Project Information

RENAL EPIGENETICS

Grant agreement ID: 293568

Project closed

Start date 1 September 2011

End date 12 July 2018

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 100 000,00

EU contribution € 100 000,00

Coordinated by

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Objective

Here, we propose a program to identify the role of mTOR and autophagy dependent epigenetic
modifications during kidney aging. We have assembled a unique set of complementary mouse models including kidney specific and timely inducible autophagy and mTOR deficient mice. For the detailed molecular analysis of transgenic podocyte tissue, we have generated a double-labeled transgenic mouse model, where podocytes expressing green fluorescent protein are contrasted by other kidney cells expressing red fluorescent protein. Using this mouse model, we have pioneered a cell sorter based purification of glomerular podocytes from kidney single cell suspensions, which allows us to perform the first epigenetic analysis of aged and transgenically modified podocytes. mTOR and / or autophagy dependent gene expression signatures, histone modifications and chromatin-remodeling patterns associated with kidney aging in transgenic and wildtype mice will be identified. We recently showed that mTOR hyperactivation at early stages of diabetic nephropathy determines the progressive course of the disease. We now hypothesize that transient mTOR hyperactivation may induce epigenetic modifications representing the clinically observed, but still unresolved “metabolic memory” of diabetic nephropathy. In
summary, this project aims to elucidate fundamental biological mechanisms of kidney aging. This may ultimately aid in risk prediction and improved targeted medical interventions to promote healthy aging and to prevent chronic kidney diseases such as diabetic nephropathy.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › clinical medicine › endocrinology › diabetes › diabetic nephropathy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › nephrology › kidney diseases

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants"

Call for proposal

FP7-PEOPLE-2011-CIG
See other projects for this call

Funding Scheme

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

UNIVERSITAETSKLINIKUM FREIBURG

• EU contribution: € 100 000,00
• Address: HUGSTETTER STRASSE 49 ; 79106 Freiburg ; Germany
• Region: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data