Objective
Quaternary ammonium compounds (QACs) are a group of antimicrobials extensively used in homes, hospitals, industrial and agricultural facilities for disinfection and sanitization purposes since 1930s. Many studies have shown that exposure to QACs leads to the selection of intrinsically resistant bacteria in a microbial community or results in the development or acquisition of resistance mechanisms. In addition, connection of antibiotic resistance, which is becoming one of the most pressing problems for human and environmental health, to the unconstrained use of antimicrobials such as QACs is, recently, under serious criticism.
QACs are lytic biocides, capable of killing over 99% of microorganisms at typical application concentrations. However, certain microorganisms that are resistant and capable of QAC degradation are present. Relatively recently, a study revealed that not only QACs but also many other antimicrobials and antibiotics are degraded by native microorganism which are potentially pathogenic in the environments critical for human and environmental health. This discovery elicits several questions: “Is biotransformation an antimicrobial resistance mechanism?” and “What is the role of biotransformation in the dissemination of antimicrobial resistance in the environment?”. The answers may have important implications on the human health, but these answers have not been given yet.
Biotransformation, whether acting as a resistance mechanism or not, plays a significant role in the fate of antimicrobial agents, and therefore, affects the dynamics of antimicrobial resistance in the environment. The overall objective of the proposed research is to systematically assess: (a) the role of QAC biotransformation on the QAC resistance of a microorganism; and (b) the dynamics of the survival of microorganisms and development of QAC resistance during QAC exposure in a community having microorganisms with different tolerance and biotransformation capacity for QACs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences public health
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
34342 Istanbul
Türkiye
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