Project description
Understanding and preventing cannula-associated thromboembolism
Kidney failure and temporary lung and heart failure may require extracorporeal organ support (ECOS). During ECOS, one access is used for blood drainage and another to return oxygenated blood. Blood flow rate in the cannula and cannulated blood vessels is often higher than physiological. Common ECOS complications include thromboembolism and morphological and mechanical changes in affected blood vessels. The EU-funded fitsCAN project focuses on the impact of blood flow at the onset of these complications using cannulae. Patient data will be used to construct laboratory and simulation frameworks, modelling the transport of substances and blood cells alongside modelling of platelet activation and risk of thrombosis during ECOS. The project results will support the development of improved cannulation techniques and new devices.
Objective
In extracorporeal organ support (ECOS), one or more organ functions fail and are replaced by an artificial device. Kidney failure requires hemodialysis, at least until transplantation. Temporary lung- and/or heart-failure may be treated by Extracorporeal Membrane Oxygenation (ECMO). About 1.5 Million patients require hemodialysis worldwide. ECMO has an essential life-saving role during the ongoing COVID-19 pandemic, as during the Influenzae H1N1 pandemic in 2009. In ECOS, two or more accesses are used; one for blood drainage and another to return oxygenated blood. The flow rate in the cannula and the cannulated blood vessels is often significantly higher than physiologically experienced. The high flow velocity implies larger forces (stress) acting on the blood cells and the vessel walls. Thromboembolism and morphological and mechanical changes in the affected blood vessel are common complications in ECOS. This project focus on the impact of blood flow on these complications. Patient-specific data (CT, MRI and Ultrasound based) will be used to construct laboratory and simulation relevant frameworks. Set-ups for measurement of flow and mixing in-vitro will be used. Simulations will include modeling of transport of chemical species and blood cells along with modeling of platelet activation and risk for thrombus formation. The different tools will enable a considerably better understanding of the underlying pathological processes. The results will support further model development of these processes and facilitate improved cannulation techniques and new devices. These propositions are to be assessed by our clinical partners. Therefore, the project group includes, fluid mechanical expertise, and also clinical specialist in nephrology, intensive care/ECMO, and radiology. The outcome of research will enable device development and clinical decision-making reducing overall treatment complications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine nephrology
- medical and health sciences clinical medicine radiology
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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HORIZON.1.1 - European Research Council (ERC)
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(opens in new window) ERC-2021-COG
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100 44 Stockholm
Sweden
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