Project description
Mechanomics to evaluate treatment
Measuring the mechanical properties of biological tissues is one way to assess how a treatment or a gene expression affects the stiffness or strength of a tissue. This is important in drug discovery, diagnostics, and genomics screening. However, current instrumentation technologies in mechanomics are outdated. The technology from the ERC-funded MECHANOMICS-POC project can apply controlled loads to tissue samples, measure the induced bulk deformations at micron level and map the distribution of local stiffness of these tissues. The technology will demonstrate the competitive potential for mechanomics. A first integrated prototype will be validated in real-world conditions in order to prepare for the market as standard laboratory equipment for drug discovery applications.
Objective
Mechanomics refers to the measurement of mechanical properties at the microscopic scale in biological tissues. Strong hopes are currently placed on mechanomics to evaluate quantitatively how a treatment or a gene expression affects the stiffness or strength of a tissue, with major impacts expected in drug discovery, diagnostics and genomics screening. However, there is a pressing need for new instrumentation technologies in mechanomics.
In the BIOLOCHANICS ERC CoG project, we developed and validated a novel multimodal technology addressing these challenges. Our technology can perform the following actions: 1. apply controlled loads on tissue samples, 2. measure the induced bulk deformations at the micron level and 3. map the distribution of local stiffness of these tissues.
Our technology shows very competitive potential for mechanomics in general. However, as an innovative technology, it remains now at the stage of a technological concept with a first laboratory application (TRL2-3) achieved within the ERC CoG BIOLOCHANICS project. Our global objective in MECHANOMICS-POC is to reach TRL 6 in order to take it further towards a commercial innovation: make a first integrated prototype, test it in an intended environment, and refine the comparison with existing technologies. Our specific objectives are (O1) to build an integrated user-friendly prototype; (O2) to determine further IPR strategy; (O3) to establish the commercialization strategy including market research, industrial partnerships and lead management; (O4) to validate the prototype in real-world conditions and present it to industrial stakeholders in the identified sectors.
Beside the development and assessment of the prototype demonstrator, we will focus on the future exploitation and commercialization roadmap of this technology, which is aimed at becoming a standard laboratory equipment or service for fundamental research in life sciences and for drug discovery applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91120 Palaiseau
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.