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ICE coupling protein inhibitors

Objective

Antibiotic resistance (AR) is one of the greatest threats to human health. The global overuse of antibiotics has resulted in the proliferation and dissemination of antibiotic resistant bacteria harboring a multitude of antibiotic resistance genes that can be mobilized by different horizontal gene transfer processes such as conjugation. Integrative Conjugative Elements (ICEs) are mobile genetic elements which are typically found integrated in the bacterial chromosome and encode the machinery for their conjugation. The so-called coupling proteins have a critical role in the conjugation process. ICECOUP is focused on the molecular and functional characterization of a critical component for ICE transmission, the coupling protein, with the ultimate goal of finding ICE conjugation inhibitors to block or, at least, minimize the AR spread. To date, ICE coupling proteins have received little attention despite their importance in the transfer mechanism. The supervision of Dr. Itziar Alkorta at the University of Basque Country(UPV/EHU) is a key element to guarantee the success of this project. ICECOUP will generate extensive and innovative scientific outputs that in the long run will have a societal impact, enhancing the catalogue of weapons to combat antibiotic resistance. The multidisciplinary approach of ICECOUP will allow me the reinforce my scientific knowledge and soft skills, while I acquire outreach and project management capacities. Undoubtedly, should this project be funded, it will strengthen my prospects to forge a stable career as an independent researcher able to secure funding.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2022-PF-01

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Coordinator

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 165 312,96
Address
BARRIO SARRIENA S N
48940 Leioa
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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