Objective
Understanding the mechanisms that generate phenotypic variation and their impact on the course of evolution is a central challenge in modern biology. The genetic architecture of development may limit or bias the phenotypic spectrum obtained after random mutation, deemed developmental bias. These phenotypic biases in turn may influence evolutionary trajectories. Despite the recognition of the importance of developmental biases in constraining and pacing evolution, there is no direct empirical evidence for this potential role.
Here, I propose to tackle this key question using the ecologically-relevant avoidance to pathogens in the genetically-tractable organism Caenorhabditis elegans. To this aim, I will: (i) quantify and uncover mechanisms of developmental biases in avoidance behaviour; and (2) test the role of developmental biases on the tempo of phenotypic evolution. On the first objective, I will generate a novel panel of random mutant lines containing a transgene for whole-organism neuronal cell-fate identification, determine developmental biases in locomotor and avoidance behaviour, and uncover mechanisms of developmental biases. On the second objective, I will construct hybrid outbred populations with varying developmental biases to test their impact on the tempo of phenotypic evolution in an ecologically relevant scenario using experimental evolution. To achieve this, I will adopt an innovative interdisciplinary approach that combines my expertise in neurodevelopmental and behaviour genetics, quantitative genetics, genome-editing and know-how with the model C. elegans with that of the host lab in experimental evolution, behaviour ecology and host-pathogen interactions. Thus, promoting an active exchange of multidisciplinary expertise between the two parties.
EvoBias will elucidate the role of developmental bias during the evolutionary process and its mechanisms in an ecologically-relevant scenario, and it will be a milestone towards my scientific independence
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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HORIZON.4.1.5 - Fostering brain circulation of researchers and excellence initiatives
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2022-TALENTS-04
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1749 016 Lisbon
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.