Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

PROTECTION FROM VIRUSES WITH EPIDEMIC AND PANDEMIC DISEASE OUTBREAK POTENTIAL THROUGH DEVELOPMENT AND CLINICAL TESTING OF A NOVEL CAPSID VIRUS LIKE PARTICLE (CVLP) VACCINE

Project description

Long-term solutions for pandemic preparedness

Epidemics and pandemics wield staggering health and economic tolls, defining critical public policy concerns globally. The need for swift understanding, response, and vaccination against potential viral threats looms larger than ever. However, modern vaccines face a pivotal challenge in inducing enduring protective immunity, as evidenced by the rapid waning of COVID-19 vaccine efficacy. In this context, the EU-funded VICI-DISEASE will develop long-term protective immunity. Specifically, the consortium aims to tackle high-mortality viral diseases like Nipah virus (NiV). By leveraging cutting-edge expertise and advancements, VICI-DISEASE strives to create a highly effective and durable NiV vaccine within 48 months. This initiative protects against NiV and Hendra virus outbreaks. It also establishes a novel pipeline for filovirus vaccines.

Objective

The enormous health and economic impacts of epidemics and pandemics has become one of the defining public policy and health issues in Europe and throughout the world. A new urgency is required to understand, rapidly respond to, and vaccinate against viruses with epidemic and pandemic potential. The major challenge for the modern vaccines is the induction of long-term protective immunity, as clearly demonstrated by fast waning of protection for current COVID-19 vaccines. VICI-DISEASE is an ambitious project which combines existing cutting-edge expertise in a tried and tested consortium, with new advances in this critical field. The consortium’s main objective is to develop a vaccine candidate portfolio and perform a clinical proof-of-concept study, to enable stocks of vaccine candidates ready for further development (Phase 2&3) in case of pandemic outbreaks. The primary candidate will be Nipah virus (NiV), a high-mortality viral disease with no vaccines or treatments. Our vaccine is based on NiV G protein displayed on capsid Virus Like Particle (cVLP), enabled by adapting template processes from our recent COVID-19 vaccine (currently in Phase 3), and expected to provide best-in-class longevity as shown for COVID-19.

The VICI-DISEASE consortium’s objective is to develop and perform a clinical proof-of-concept study for
• a highly effective (>90% protection),
• long-term protective (>2 years),
• NiV virus cVLP vaccine,
• by adapting template processes established for our COVID-19 vaccine (currently in Phase 3),
• within 48 months in a Phase 1/2a clinical study,
• to help protect medical workers and the public from future NiV and Hendra virus outbreaks,
• and establish a pipeline of novel filovirus vaccines through pre-clinical proof-of-concept studies.

We address the call topic by improving pandemic preparedness and response through development of a NiV vaccine to Ph1/2 and two filovirus vaccines to pre-clinical proof-of-concept.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

You need to log in or register to use this function

Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-RIA - HORIZON Research and Innovation Actions

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-HLTH-2023-DISEASE-03

See all projects funded under this call

Coordinator

KOBENHAVNS UNIVERSITET
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 546 141,25
Address
NORREGADE 10
1165 KOBENHAVN
Denmark

See on map

Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 546 141,25

Participants (5)

Partners (2)

My booklet 0 0