Project description
Microbial lipid metabolites and intestinal regeneration
The gut microbiota is a complex community of microorganisms that plays a fundamental role in digestion, immunity and epithelial regeneration. Disruption of host-microbiota interactions is a key feature of diseases like inflammatory bowel disease and colorectal cancer. With the support of the Marie Skłodowska-Curie Actions programme, the GUTMATES project aims to investigate the nature of host-microbiota interactions and especially the role of the lipid metabolites octadecanoids from 18-carbon fatty acids. Researchers will use a multidisciplinary approach to explore the influence of these metabolites in mucosal repair, which has been understudied in relation to gut disease outcomes. Project findings will lay the foundation for regenerative therapeutics driven by gut microbiota.
Objective
The microbiota-host crosstalk is crucial for several processes in the gut and its dysregulation is a hallmark of diseases such as colorectal cancer (CRC) and inflammatory bowel disease (IBD). Despite its key relevance for a holistic understanding of human (patho)physiology, how this crosstalk affects the cellular and molecular programs in the intestine remains is yet to be fully understood, mainly due to a lack of suitable technologies and models. It is known that one of the ways that the gut microbiota interacts with the host is via metabolite production. Among these, octadecanoids, lipid mediators from 18-carbon (18-C) polyunsaturated fatty acids, are poorly studied in the context of the gut despite their high abundance and diversity. Studies on this topic have only focused on inflammation, neglecting the mucosal healing response, highly relevant for IBD outcome and CRC tumorigenesis. In GUTMATES, I will use a new zebrafish model of intestinal damage/regeneration- and organoid-based screening platforms, together with murine colitis models, spatial transcriptomics, metabolomics, metagenomics, and clinical readouts to visualize the effect of microbial octadecanoids in intestinal regeneration. This project will provide the first large-scale exploration of how these metabolites modulate the mucosal healing process in vivo, as well as giving a multi-omic atlas of the impact of selected 18-C compounds in the mouse colon during regeneration. My ultimate aim with GUTMATES is to have a comprehensive view of the mucosal healing landscape given by gut microbial octadecanoids, to eventually find compounds or microbes that can be exploited for regeneration-based therapies in IBD and biomarkers for CRC.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.