Objective
Resveratrol (3,4',5-trihydroxystilbene) and its derivatives (e.g. pterostilbene, piceatannol, and viniferin) are naturally occurring compounds found in plants and have various medicinal properties, including anti-inflammatory, antimicrobial, anti-cancer and many other activities. Therefore, they are commercialised as components of many medicines, nutritional supplements, healthy foods, and cosmetics. However, plants typically have low concentrations of resveratrol (e.g. 5.1 μg/g in peanut and 3.9 mg/g in Rheum rhaponticum). Extracting resveratrol from plants is a traditional method with notable drawbacks, including long growth times (several years), high costs, low yields, land and labor waste, and pollution of the environment. The chemical synthesis of resveratrol involves complex steps, uses hazardous solvents, and generates toxic byproducts. Due to these reasons, biotechnological production of resveratrol by recombinant microorganisms is a promising strategy to solve the above issues. The current production of resveratrol synthesised by mono-culturing yeast remains relatively low, with productions in shake flasks being less than 1 g/L.
Microbial co-culture is a cooperation strategy where microorganisms survive by feeding on the metabolic products of neighbors. This approach alleviates the significant metabolic burden associated with engineering a single strain to handle the entire biosynthetic pathway of metabolites. It promises to increase final production compared to the mono-culture. This proposed study relates to a novel approach in resveratrol biosynthesis by Y. lipolytica, which will address a critical question in today's resveratrol biosynthesis research: can the co-culture of Y. lipolytica engineered strains using lignocellulose as a sustainable carbon source significantly improve resveratrol production and promote the industrialisation of resveratrol biosynthesis in Europe?
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.