Objective Traditional preclinical discovery methods, particularly for target validation, poorly predict drug efficacy, causing a high attrition rate in costly late-stage clinical trials. The PREDECT consortium will focus on complex but transferable, next generation in vitro and in vivo models for breast, prostate and lung cancers. Models will be investigated for their improved potential to validate novel therapeutic targets. Known targets, in canonical pathways, will be interrogated for induction of phenotypic, proteomic and transcriptomic changes using inhibitors. A strategy of seeking a ‘dynamic reciprocity’ of concordance between the steady and perturbed states of in vitro complex cultures, tissue slices and in vivo tumour models will be pursued by systems biology analyses. Comparison with historic gene expression and genomic data from relevant clinical materials should permit the emergence of faithful models for target validation and beyond. PREDECT is coordinated by Servier and AstraZeneca, and the managing entity of IMI JU funding is the University of Helsinki. The team assembles world-class biologists, clinicians and computational scientists from 8 prestigious EU institutes, 3 SMEs and 8 EFPIA members to develop and critically assess models for target validation. The interaction between pharmaceutical and academic participants will be proactive, through postdoc co-supervision and work package co-piloting. We propose to develop and generate a repository of advanced complex models in 3 complementary areas: (i) in vitro 2D/3D organotypic (co-)cultures, stirred bioreactor aggregates and tissue slice systems; (ii) novel (orthotopic) grafts of human and mouse tumour samples; and (iii) genetically-engineered and mosaic mouse models. The deliverables of PREDECT are expected to shift paradigms in target validation, permitting greater predictivity of drug efficacy in patient cohorts. Fields of science engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesclinical medicineoncologylung cancer Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-02-2009-01 - Oncology – Target Validation Call for proposal IMI-JU-02-2009 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator INSTITUT DE RECHERCHES SERVIER EU contribution No data Address 3 Rue de la Republique 92150 Suresnes France See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator John Angus HICKMAN (Dr) Administrative Contact John Angus HICKMAN (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (20) Sort alphabetically Sort by EU Contribution Expand all Collapse all HELSINGIN YLIOPISTO Finland EU contribution € 3 284 288,00 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Tiina Berg (MRS) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEKNOLOGIAN TUTKIMUSKESKUS VTT Participation ended Finland EU contribution € 495 294,00 Address TEKNIIKANTIE 4 A 02044 VTT ESPOO See on map Activity type Research Organisations Administrative Contact Sinikka Soirinsuo (MRS.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 649 980,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Cathrin BRISKEN (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 774 994,00 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (MS.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA Portugal EU contribution € 197 660,00 Address AVENIDA DA REPUBLICA QUINTA DO MARQUES 2781-901 Oeiras See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Administrative Contact Elsa Vieira (MS.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 309 613,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Maarten Van Langen (MR.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 1 082 944,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Ellen Schenk (DR.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TARTU ULIKOOL Estonia EU contribution € 399 336,00 Address ULIKOOLI 18 51005 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Higher or Secondary Education Establishments Administrative Contact Martin Kaljula (MR) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH Germany EU contribution € 812 984,00 Address AM FLUGHAFEN 12-14 79108 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Zakia Amalou (DR.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Biomedicum Genomics Ltd Finland EU contribution € 388 920,00 Address Haartmaninkatu 00290 Helsinki See on map Administrative Contact Outi Maria Monni (DR) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASTRAZENECA AB Sweden EU contribution No data Address Vastra Maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Camilla Olausson (DR) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Bayer Pharma AG Germany EU contribution No data Address Muellerstrasse 178 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Burkhardt Neumann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ORION OYJ Finland EU contribution No data Address ORIONINTIE 1 02200 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Reijo Salonen (DR) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data F. HOFFMANN-LA ROCHE AG Switzerland EU contribution No data Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jason Hannon (MR) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Participation ended Italy EU contribution No data Address Viale Shakespeare 00144 Roma See on map Administrative Contact Pietro Grossi (Dr.) Links Contact the organisation Opens in new window Total cost No data BOEHRINGER INGELHEIM INTERNATIONALGMBH Germany EU contribution No data Address BINGER STRASSE 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Erik Patzelt (DR.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROBERT BOSCH GESELLSCHAFT FUR MEDIZINISCHE FORSCHUNG MBH Germany EU contribution € 339 864,00 Address AUERBACHSTRASSE 112 70376 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Research Organisations Administrative Contact Christiane Schmiedl (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JANSSEN PHARMACEUTICA NV Belgium EU contribution No data Address TURNHOUTSEWEG 30 2340 Beerse See on map Region Vlaams Gewest Prov. Antwerpen Arr. Turnhout Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henk Sipma (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CARDIFF UNIVERSITY United Kingdom EU contribution € 20 764,00 Address NEWPORT ROAD 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Administrative Contact Eevi Laukkanen (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ABBVIE INC United States EU contribution No data Address NORTH WAUKEGAN ROAD 1 60064 North Chicago Il See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Keith Glaser (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data