Objective Ageing is a fundamental biological process that defines all aspects of life, yet the understanding of the basic biological interactions leading to ageing and how genetic and environmental variation contributes to this processes are still largely unknown. We propose to use the most up to date genomic and epidemiological methodologies to shed light in some of the key questions in ageing research. We will use whole transcriptome sequencing, and telomere length assays in three cell types of 855 twins for which a large set of phenotypic measurements relating to ageing are available. These datasets will be integrated with genome-wide association studies in a systems genetics framework to infer causal interactions (genetic or environmental). The combination of these unique datasets together with the expertise of the participants is likely to provide novel insights to ageing research and uncover currently unknown factors that contribute to variation in the ageing process in human populations. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesbiological behavioural sciencesethologybiological interactions Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.2.2-4 - Markers of cellular senescence for human ageing. FP7-HEALTH-2010-two-stage Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KING'S COLLEGE LONDON EU contribution € 1 179 286,00 Address STRAND WC2R 2LS London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all GENOME RESEARCH LIMITED United Kingdom EU contribution € 237 728,00 Address WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS HINXTON CB10 1SA SAFFRON WALDEN See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Administrative Contact Richard Durbin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution € 1 094 400,00 Address RUE DU GENERAL DUFOUR 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Emmanouil Dermitzakis (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III Spain EU contribution € 381 179,75 Address C MELCHOR FERNANDEZ ALMAGRO 3 28029 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Laura Bertolini (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIFE LENGTH SL Spain EU contribution € 106 056,00 Address CALLE MIGUEL ANGEL 11 2 PLANTA 28010 MADRID See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stephen Matlin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data