Objective The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in delivering full therapeutic benefits to DBS patients while preventing the stimulation-induced side-effects that occur with today's DBS implants.PD is well known for its characteristic symptoms: shaking, rigidity, slowness of movement and postural instability. Millions are suffering from PD including famous people like Michael J. Fox. Drugs are used as first treatment, but as the disease progresses they become ineffective and increasingly higher doses are needed. This leads to many side-effects, while symptoms still persist.DBS is a ‘pacemaker for the brain’, analogous to the function of pacemakers for the heart: mild electrical stimuli are delivered to brain tissue to suppress unwanted activity and restore desired neuronal functions. When stimulation is optimal, the impact of DBS is spectacular: shaking and rigidity are strongly improved, and medication doses may be lowered significantly.Despite its successes, DBS is still in its infancy. Programming for optimal therapy is complicated since physicians lack the appropriate tools to support them. Around 15 – 30% of DBS patients suffer from stimulation-induced side-effects resulting from stimulation leaking outside intended target regions. IMPACT addresses these barriers to adoption exploiting the directivity provided by next generation high-resolution implants.IMPACT delivers a physician tool for tuning the high-resolution implant based on a personalized patient brain stimulation model that takes into account imaging data (MRI, X-ray) as well as pre-operative data (local field potentials). Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MEDTRONIC BAKKEN RESEARCH CENTER B.V. EU contribution € 1 847 180,00 Address ENDEPOLSDOMEIN 5 6229GW Maastricht Netherlands See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Daniel Schobben (Mr.) Links Contact the organisation Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all SAPIENS STEERING BRAIN STIMULATION BV Participation ended Netherlands EU contribution No data Address High Tech Campus 41 5656 AE Eindhoven See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Daniel Schobben (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ICSENSE NV Belgium EU contribution € 502 215,00 Address GASTON GEENSLAAN 14 3001 Leuven (Heverlee) See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. 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