Objective
It is unquestioned that early detection of cancer is a major factor contributing to therapy outcome. Unfortunately, only
few tumour markers have been identified for early stage cancers to date, and the reliable detection of tumours before the manifestation of morphological changes still remains an unresolved problem in routine clinical diagnosis. A recent study came to the conclusion that shedding rates of currently available cancer biomarkers are a factor of 10-4 below the necessary sensitivity to reliably detect cancers during their first decade. In other studies, the reliability of currently existing biomarkers such as the PSA-marker for prostate cancer is questioned. The development of alternative early-stage tumour markers, in particular also for epithelial cancers, is therefore urgently necessary.
FLOWERFIELDS is aimed to provide means and methods to detect such cancer cells before an aggressive tumour is
formed. To that end, we plan to exploit the extracellular molecular code called “The Flower Code” (Fwe) that is expressed in very early stage cancer or precancerous cells. Fwe may be integrated into routine immuno- or PCR-assays for the detection of a variety of epithelial cancers. Applications may include early-stage diagnosis but also the evaluation of therapy outcome.
The current project has two aims: (i) to develop improved ligands for ELISA diagnostic tests for Flower gene expression, (ii) to validate the concept clinically on human samples in both immuno- and PCR-based assays. The clinical validation of a biomarker candidate is a key success factor for being able to feed it into development stage of a commercial partner.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences biochemistry biomolecules proteins
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-PoC
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
3012 BERN
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.