Osteo-inductive coating of orthopedic and dental implants

Objective

"In the field of orthopedics, the contact with an implant and the new bone forming is very important to ensure a proper osteo-integration of the implant. One of the challenges is to boost bone regeneration, to limit the number of surgeries and to decrease the hospitalization time in order to reduce the costs. The nature of the implantable materials used in clinical practice is very diverse as metal, ceramics and polymers are commonly used depending on the specific application and needs.
The strategies already used in clinics are based on two major routes: 1) use of osteoconductive materials or osteoconductive coatings, such as ceramic coatings, which will help to improve the connexion between the new bone forming and the implant. 2) use of osteo-inductive implants that will induce bone regeneration. The only way to achieve this osteo-induction is to deliver a bioactive protein, which is a growth factor from the bone morphogenetic family (BMP). BMP-2 and BMP-7 are two members of this family already used in practice in spine, long bone and cranio-facial surgery. However, currently, their use is limited to collagen sponges or paste, to which they are associated and poorly retained. In fact, due to this poor retention, a very high amount of BMP (typically 10 mg) is required. This leads to a high cost of the product and to possible risks of adverse side effect, notably immunogenic reaction.
In this context, the current challenges are : i) to deliver these BMPs from the surface of other materials, especially polymers and metallic alloy already used in clinical practice, ii) to deliver them efficiently at much lower doses. This requires the engineering of new types of osteo-inductive surface coatings.
The aim of the current project is to prove that the BMP loaded films developed in the framework of the ERC StG project BIOMIM are an innovative solution to render the surface of implants osteo-inductive."

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences clinical medicine odontology dental implantology
• medical and health sciences clinical medicine surgery
• natural sciences chemical sciences polymer sciences
• engineering and technology materials engineering coating and films
• medical and health sciences medical biotechnology implants

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

• ERC-OA-2012-PoC - European Research Council ERC Proof of Concept

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

ERC-2012-PoC
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

Beneficiaries (1)