Project description
The microscopes of tomorrow
Laser-based optical microscopy is a powerful method of generating high-resolution images by scanning objects with a laser. Detection and quantification of tissue biomolecules in microscopy takes place through sample staining which can create artefacts. The key objective of the EU-funded MUSIQ project is to develop the next generation of optical microscopes with a capacity for quantitative imaging at the single-cell level. The project has recruited early career researchers to work on the incorporation of spectroscopy and coherent Raman scattering modalities that allow optical imaging of biomolecules without the need for labelling.
Objective
In the quest to decipher the chain of life from molecules to cells, the biophysical questions being asked increasingly demand techniques that are capable of identifying specific biomolecules in their native environment at the smallest possible scale, and measuring their interactions quantitatively without perturbing the system under observation. Laser-based optical microscopy is a key technology to drive this progress in the 21st century. Still, many challenges remain in particular toward i) achieving imaging with biomolecular specificity without the artefacts from sample staining, ii) quantitative imaging, and iii) single molecule sensitivity. Progress toward biomolecular specificity at very high temporal resolution has been brought by the development of ultrafast two-dimensional electronic spectroscopy, able to address the importance of quantum coherences with the potential to unravel the fundamental machinery of Nature. Yet, measuring quantum phenomena with an optical microscope is technically challenging, and far from real-world biological applications. MUSIQ is designed as an innovative research and training network, where we will recruit 15 Early Stage Researchers to work toward the central ambitious goal of developing the next-generation optical microscopy exploiting quantum coherent nonlinear phenomena. The network brings together a unique team of 7 world-leading academics and 6 high tech companies at the forefront of optical microscopy and ultrafast laser technology developments merged with fundamental understanding of coherent light-matter interaction phenomena, development of quantitative image analysis tools, and biomedical/pharmaceutical real-world applications. MUSIQ will establish an intersectoral training and research programme at the physics/chemistry/life science interface with partners from 9 European countries, aimed at creating the next generation of skilled well-connected scientists that will pioneer the ‘quantum microscopes of tomorrow’.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences physical sciences optics microscopy
- natural sciences physical sciences optics laser physics ultrafast lasers
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-ITN-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CF10 3AT CARDIFF
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.