Project description
Developing cost-efficient organ-on-a-chip technology
With developments in microengineering and the spread of digitalisation, new technologies can be developed in a variety of sectors. Biology is a good example, with the appearance of Organ on-chip (OoC) technology. This technology would greatly assist researchers in both the discovery and development of drugs and improve precision in personalised medicine as well as reduce the need for animal testing. Unfortunately, due to its complexity, the transition to large-scale manufacturing and commercial use from the laboratory is proving difficult. The EU-funded SmOoC project will assist in this transition by introducing a smart OoC system utilising multimode lamb waves inside a microfluidic system. This will allow for the cost-effective production and application of OoCs.
Objective
Organ on chip (OoC) is a remarkable example of the convergence of biology and microengineering. OoC has a great potential in revolutionizing the current existing in-vitro approach in drug discovery and development, resulting in a reduction in the needs of animal experiment and accelerate the research and development process for future precision and personalised medicine. However, the complexity of the system is a hurdle in the transfer of OoC system from laboratory to large scale manufacturing and commercial application. The miniaturisation and integration of sensing and actuation components is an important aspect to be addressed to ensure manufacturability of the system. Moreover, a closed loop control system is required to create a smart OoC system that can operate dynamically to process the information and make decisions in a predictive or adaptive manner.
The objective of this proposed research project is to develop a smart OoC system by utilising multimode Lamb waves for sensing, actuation, and control, integrated within a microfluidic system. The action will combine the researcher expertise and experience in higher order multimode Lamb wave, microelectromechanical system (MEMS) and smart system integration, with the supervisors and the host institute experiences in acoustic wave sensor and the integration with microfluidics for biological application. Furthermore, the action will be complemented by a secondment in a non-academic partner that is intended for translational research to bring the technological solution into medical practice. The successful result of this action will contribute to the development of cost effective, automated smart OoC system that is suitable for large scale manufacturing to bridge the gap between laboratory and commercial application for drug discovery and future personalised medicine
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering control systems
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences health sciences personalized medicine
- engineering and technology other engineering and technologies microtechnology organ on a chip
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
25000 Besancon
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.