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Results 1 - 10 of 11780
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Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity
ID: 294880
Anfangsdatum: 2012-04-01, Enddatum: 2017-03-31
Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin cha...
Programme: FP7-IDEAS-ERC
Record Number: 102711
Last updated on: 2017-05-08
Final Report Summary - UB-DECODED (Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity)
TNF is a pro-inflammatory cytokine which plays a crucial role in response to infections, auto-immunity and cancer related-inflammation. Poly-ubiquitination has emerged as a master-regulator of signalling pathways. Eight types of poly-ubiquitin chains have been described and...
Programme: FP7-IDEAS-ERC
Record Number: 208658
Last updated on: 2017-11-16
Final Report Summary - FLIESCAN (Modelling  Cancer Traits in Drosophila)
FliesCan has explored the potential of the vinegar fly Drosophila melanogaster to implement new experimental models to tackle cancer. Despite obvious anatomical and physiological differences, malignant tumours in humans and flies are made of cells that derail from their normal...
Programme: FP7-IDEAS-ERC
Record Number: 208725
Last updated on: 2017-11-16
p53 as a New Mediator of Energy Balance in the Brain
ID: 281408
Anfangsdatum: 2011-12-01, Enddatum: 2017-05-31
p53 is a transcriptional factor modulating numerous biological actions. Although it is best known for its role in cancer development, it is now evident that it is implicated in metabolism. More specifically, p53 modulates energy metabolism and homeostasis through their effect...
Programme: FP7-IDEAS-ERC
Record Number: 100931
Last updated on: 2016-08-29
Final Report Summary - OBESITY53 (p53 as a New Mediator of Energy Balance in the Brain)
In this project we are evaluating the potential of brain p53 as an anti-obesity and/or anti-diabetic drug candidate. To achieve this, we have designed a strategy that includes genetically-manipulated mice approaches. In this sense, we have found that brain p53 is necessary for...
Programme: FP7-IDEAS-ERC
Record Number: 208635
Last updated on: 2017-11-16
Final Report Summary - MOTOGLIA (Axoglial synapses, adult myelination and motor skills learning)
We showed (Young et al., 2013) that oligodendrocytes precursors (OPs) continue to proliferate and differentiate into myelinating oligodendrocytes throughout young adult life in mice, raising questions about the function of the late-born cells. We also showed that lateborn...
Programme: FP7-IDEAS-ERC
Record Number: 208733
Last updated on: 2017-11-16
Modelling  Cancer Traits in Drosophila
ID: 294603
Anfangsdatum: 2012-07-01, Enddatum: 2017-06-30
Despite significant advance, cancer treatment remains suboptimal. Anatomical and physiological differences between humans and simple model organisms like Drosophila are many and major, and preclude the modelling of key aspects of the disease as it proceeds in vertebrates. How...
Programme: FP7-IDEAS-ERC
Record Number: 102724
Last updated on: 2016-03-18
High value-added chemicals and BIoreSIns from alGae biorefineries produced from CO2 provided by industrial emissions
ID: 613680
Anfangsdatum: 2013-11-01, Enddatum: 2017-04-30
BISIGODOS aims to address the production of valuable algae derived chemicals, amino acids and high added-value bio-resins for coatings, printing, food and hair care and adhesives applications, starting from algae biomass fed directly with CO2 from industrial emissions (cement...
Programme: FP7-KBBE
Record Number: 110873
Last updated on: 2016-07-08
Final Report Summary - BISIGODOS (High value-added chemicals and BIoreSIns from alGae biorefineries produced from CO2 provided by industrial emissions)
BISIGODOS is a 42-month project that aims at the production of high value-added algae derived chemicals and bio-resins for flexible packaging, coatings, printing, food and hair care applications. The starting raw material is cost-effective and renewable algae biomass, which is...
Programme: FP7-KBBE
Record Number: 208639
Last updated on: 2017-11-16
Axoglial synapses, adult myelination and motor skills learning
ID: 293544
Anfangsdatum: 2012-03-01, Enddatum: 2017-02-28
"Recently it has become clear that new oligodendrocytes and myelin are generated throughout adult life in rodents. Some major axon tracts including the corpus callosum contain a majority of unmyelinated axons even in maturity, suggesting that at least some of the adult-born o...
Programme: FP7-IDEAS-ERC
Record Number: 102521
Last updated on: 2016-06-27
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List retrieved on: 2017-11-18
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