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IMPROVED RETROGRADE LENTIVIRAL VECTORS FOR GENE THERAPY IN MOTOR NEURON DISEASES
ID: 233147
Anfangsdatum: 2009-04-01, Enddatum: 2014-08-31
Lentiviral vectors can be targeted to specific cell types by varying the envelope proteins, a process called pseudotyping. The rabies-G pseudotyped lentivectors are useful for distal targeting of neurons because they are retrogradely transported to the nucleus where they inte...
Programme: FP7-IDEAS-ERC
Record Number: 89779
Last updated on: 2017-05-25
Periodic Report Summary 2 - MALONCO (Targeting cancer using evolutionary refined pathogen derived antigens)
As an immune evasion survival strategy the P. falciparum malaria parasite has evolved a protein named VAR2CSA, which mediates parasite binding in the placenta through interaction with uniquely sulfated Chondroitin Sulfate A (CSA) proteoglycans on the throphoblast cells...
Programme: FP7-IDEAS-ERC
Record Number: 202318
Last updated on: 2017-08-14
Periodic Report Summary 2 - HIV LTR G-4 (G-quadruplexes in the HIV-1 genome: novel targets for the development of selective antiviral drugs)
Screening In the first 30 months of the project, we have found and developed four small molecules that display anti-HIV-1 activity: one G-quadruplex (G4) ligand that inhibits HIV-1 with effective concentration (EC50) in the low micromolar range. To improve selectivity we have...
Programme: FP7-IDEAS-ERC
Record Number: 201441
Last updated on: 2017-07-24
Periodic Report Summary 2 - BARCODE (The use of genetic profiling to guide prostate cancer targeted screening and cancer care)
The BARCODE project is divided into two studies which are aiming to utilise knowledge of the genetic risk of prostate cancer to target screening to high risk men in the community, and also to offer effective treatment options to men who develop prostate cancer based on...
Programme: FP7-IDEAS-ERC
Record Number: 202261
Last updated on: 2017-08-14
Periodic Report Summary 2 - GLYCOTREAT (Novel vaccine generation for the treatment of cancer. A glyco-nanomedial approach instructing T cells)
The Glycotreat project aims to develop new glycan based nanomedicines to target to DC for the induction of powerful T-cell responses to treat cancer. In this project we focus on two types of cancer: one induced by viruses, and the other with a focus on self-antigen melanoma...
Programme: FP7-IDEAS-ERC
Record Number: 201447
Last updated on: 2017-07-24
Periodic Report Summary 2 - OMVAC (Outer Membrane Vesicles (OMVs) from “Vaccinobacter”: A Synthetic Biology approach for effective vaccines against infectious diseases and cancer)
Executive Summary The main objective of the OMVac project is to apply Synthetic Biology to create a new bacterial species, Vaccinobacter, devoted to the production of multivalent, highly effective vaccines against infectious diseases and cancer. The project is organized in...
Programme: FP7-IDEAS-ERC
Record Number: 201444
Last updated on: 2017-07-24
Final Report Summary - I-MIRNOME (Lymphocyte microRNAs in health and disease: Understanding lymphocyte functions through the identification of microRNA target genes and exploiting serum microRNA signatures to monitor immune responses)
CD4+ T cell subsets are not only specialised to fight different classes of pathogens, but are also major drivers of immune mediated diseases. Differentiation of CD4+ T cells subsets has been extensively investigated at the gene expression level, but little is known on the...
Programme: FP7-IDEAS-ERC
Record Number: 199881
Last updated on: 2017-06-21
Final Report Summary - BREATHE (BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn)
BREATHE (BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn) is a population neuroscience study assessing whether exposure of children to traffic related air pollutants (TRAPs) in schools adversely affects neurodevelopment. Exposure to TRAPs during...
Programme: FP7-IDEAS-ERC
Record Number: 199873
Last updated on: 2017-06-21
Periodic Report Summary 2 - BIO-PHONONICS (Advanced Microfluidics & Diagnostics using Acoustic Holograms – Bio-Phononics)
Synopsis of Outcomes: One important aim of this application has been the development of a new understanding of the physics and engineering of the interactions between sound and liquid interfaces within phononic structures. These phononic structures can be considered analogous...
Programme: FP7-IDEAS-ERC
Record Number: 199502
Last updated on: 2017-06-21
Mid-Term Report Summary - NIPD (A Novel Non-Invasive Prenatal Diagnosis for Genetic Disorders)
The main objective of the project is to develop and validate a novel non-invasive prenatal test for the identification of genetic diseases and syndromes, which are caused by aneuploidies, copy number changes or point mutations. We successfully identified thousands of fetal...
Programme: FP7-IDEAS-ERC
Record Number: 197669
Last updated on: 2017-05-16
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List retrieved on: 2017-09-26
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