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Post-genomic datamining of enzymes for the synthesis of chiral pharmaceutical intermediates
ID: 503017
Start date: 2003-12-01, End date: 2006-11-30
Chirality is a key factor in the efficacy of many drugs and the production of single enantiomers of chiral intermediates has therefore become increasingly important. Biocatalysis offers high enantioselectivity and regioselectivity in chiral synthesis through enzyme-catalyzed r...
Record Number: 75267
Last updated on: 2009-12-23
Integrated genomics, clinical research and care in hypertension
ID: 37093
Start date: 2006-11-01, End date: 2011-01-31
The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics,...
Record Number: 84934
Last updated on: 2013-03-26
Development of New Drugs for the Treatment of Malaria
ID: 18834
Start date: 2005-12-01, End date: 2011-05-31
Leading groups of malaria researchers will integrate their expertise in malaria biology and drug development to exploit new scientific and political opportunities to secure the development of a portfolio of viable novel AntiMalarial drugs. New chemical entities will be commerc...
Record Number: 78405
Last updated on: 2011-12-20
Genetic and environmental determinants of melanoma: translation into behavioural change
ID: 18702
Start date: 2005-12-01, End date: 2011-05-31
GenoMEL, formerly known as the Melanoma Genetics Consortium, has focused on the identification of familial high penetrance melanoma genes. The joint programme of research has been very successful in the identification of susceptibility genes and developing joint data collectio...
Record Number: 84807
Last updated on: 2011-07-26
Epigenetic treatment of neoplastic disease
ID: 518417
Start date: 2005-11-01, End date: 2011-04-30
Chromatin is epigenetically modified to regulate gene expression. Upstream signals induce complex patterns of enzyme-catalyzed modifications of DNA and histones, key protein components of chromatin. These epigenetic modifications create docking sites for other regulators and f...
Record Number: 78780
Last updated on: 2011-05-30
Alzheimer's disease-treatment targeting truncated Aß40/42 by active immunisation
ID: 37702
Start date: 2006-10-01, End date: 2010-12-31
Alzheimer's disease (AD) is the most common form of dementia in humans. According to the Alzheimer Association there are currently 12 million patients worldwide with estimated social costs for every patient reaching 40,000 per year. At present, no effective treatment is availa...
Record Number: 85029
Last updated on: 2011-01-24
European Rat Tools for Functional Genomics
ID: 19015
Start date: 2006-03-01, End date: 2010-08-31
Determining the molecular basis of natural phenotypic variation, including inter-individual susceptibility to common diseases, is a central challenge of post-genome genetics. The rat is a leading model species for research in physiology, pharmacology and toxicology, and for th...
Record Number: 78568
Last updated on: 2010-10-14
Identification of early disease markers, novel pharmacologically tractable targets and small molecule phenotypic modulators in Huntington's Disease'
ID: 37472
Start date: 2007-01-01, End date: 2010-12-31
Huntington's is a devastating neurodegenerative disease with many unmet patient needs. There are no known ways of slowing or preventing the neuro-degeneration, and clinical trials in man are hampered by the slow disease progression and the absence of suitable biomarkers of sho...
Programme: FP6-IST
Record Number: 96397
Last updated on: 2011-01-24
ENFIN - an experimental network for functional integration
ID: 518254
Start date: 2005-11-15, End date: 2011-05-14
We propose to form a Network of Excellence in the area of bioinformatics to provide a Europe-wide integration of computational approaches in systems biology. This network will be focused on the development and critical assessment of computational approaches in this area, but u...
Record Number: 75903
Last updated on: 2013-03-26
Reprogramming the immune System for the Establishment of Tolerance
ID: 512090
Start date: 2005-03-01, End date: 2010-08-31
Transplantation dramatically improves the survival of patients with end-stage failure of vital organs. However, as a directconsequence of the immunosuppressive drugs permanently required to prevent rejection, recipients have a significantly increased risk of infection and mali...
Record Number: 75691
Last updated on: 2010-10-12
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List retrieved on: 2017-05-23
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