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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Thermal fatigue evaluation of piping system
ID: FIKS-CT-2001-00158
Start date: 2001-12-01, End date: 2004-11-30
Thermal fatigue is a recurring problem when LWR plants become older and life time extension activities are initiated. In general, the common thermal fatigue issues are understood and can be controlled by plant instrumentation systems. However, the Civaux 1 and other incidents ...
Programme: FP5-EAECTP C
Record Number: 59924
Last updated on: 2003-04-01
Safety and operational monitoring of nuclear waste repositories with fiber optic sensing systems
ID: FIKW-CT-2001-00190
Start date: 2001-12-01, End date: 2004-11-30
To guarantee operational safety during the operational phase of a final repository, monitoring systems are indispensable. At the same time, long-term safety analysis performed prior to the construction and operation, can be verified by the measurements obtained during the oper...
Programme: FP5-EAECTP C
Record Number: 59927
Last updated on: 2003-12-02
Telomeres and radiosensitivity of individuals
ID: FIGH-CT-2002-00217
Start date: 2003-01-01, End date: 2005-12-31
Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that ...
Programme: FP5-EAECTP C
Record Number: 67972
Last updated on: 2003-04-01
Effects of telomerase and telomere length on epidermal stem cell behaviour
In the past, Maria Blasco and her team have shown that mice with critically short telomeres are highly sensitive to ionising radiation, i.e. show increased chromosomal instability upon gamma irradiation. More recent results shed light on the mechanism underlying telomere-drive...
Programme: FP5-EAECTP C
Record Number: 44389
Last updated on: 2007-08-22
Mouse models of telomerase overexpression
In the past, Maria Blasco and her team (partner CNIO) have shown that the telomerase reverse transcriptase component (Tert) may favour growth and survival independently of telomere length maintenance. They have generated two mouse models that over-express Tert under the kerati...
Programme: FP5-EAECTP C
Record Number: 44388
Last updated on: 2007-08-22
Novel mechanisms of telomere maintenance
During the progression of Telosens work, novel mechanisms of telomere maintenance were identified. Previous work of Maria Blasco and her team (partner CNIO) provide evidence for the implication of epigenetic mechanisms in the regulation of mammalian telomere length and functio...
Programme: FP5-EAECTP C
Record Number: 44387
Last updated on: 2007-08-22
Impact of telomere dysfunction on the cellular and organismal response to radiation and genotoxic agents
In the past, Maria Blasco and her team (partner CNIO) have shown that mice with critically short telomeres are highly sensitive to ionising radiation, i.e. show increased chromosomal instability upon gamma-irradiation. More recent results from a close collaboration between par...
Programme: FP5-EAECTP C
Record Number: 44385
Last updated on: 2007-08-22
Role of DNA repair proteins in telomere function
To further define the role of DNA repair proteins in telomere function and telomere-driven radiosensitivity, Maria Blasco and her team (partner CNIO) has studied cells from mice deficient for the DNA repair proteins Ku86, DNA-PKcs, and PARP-1. Previous work of partner CNIO sho...
Programme: FP5-EAECTP C
Record Number: 44386
Last updated on: 2007-08-22
Telomeres modulate radiation response in vitro and in vivo - Vegetable intake prevents excessive telomere shortening
Mouse studies in the frame of this and previous EU project have determined that telomere length modulates radiosensitivity. Thus, telomerase KO mice with short telomeres (late generation) are more sensitive that telomere KO mice with long telomeres (earlier generation KO mice)...
Programme: FP5-EAECTP C
Record Number: 44384
Last updated on: 2007-08-22
Telomere and whole genome tri-dimensional reconstruction of inter-phase nuclei architecture in response to ionising radiation
Jordi Surralles' objective was to study the architecture of the inter-phase nuclei from the telomere perspective and it response to ionising radiation. He found that telomeres have a defined 3D distribution pattern inside the interphase nucleus that is independent of histone H...
Programme: FP5-EAECTP C
Record Number: 44383
Last updated on: 2007-08-22
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List retrieved on: 2018-01-22
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