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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Towards an optimal strategy for optimal vitamin d fortification
ID: QLK1-CT-2000-00623
Start date: 2001-01-01, End date: 2004-06-30
Nutrient additions to the human food chain include vitamin D incorporated in a wide variety of fatty foods. Against this background, the proposal addresses the Sol Work Program calling for the 'development of foods with particular benefit in Population groups such as - childre...
Programme: FP5-LIFE QUALITY
Record Number: 54281
Last updated on: 2005-04-12
Vitamin D fortified bread
[REPORT SUMMARY] Vitamin D fortified bread
Fortification of non-fatty foods such as bread could be a feasible means to improve the vitamin D status, which is generally low in Northern countries during winter. Fortified wheat and rye bread were baked. The vitamin D preparation was water soluble powder delivered by Roche...
Programme: FP5-LIFE QUALITY
Record Number: 39089
Last updated on: 2006-02-28
Trophic signaling by gdnf family ligands and their receptors in neuronal development and repair (GDNF)
ID: QLG3-CT-2002-01000
Start date: 2002-09-01, End date: 2005-08-31
The goal of this project is to elucidate novel molecular and cellular mechanisms of nervous system development and repair using the paradigm of the GDNF family offloads and their receptors. GDNF is a potent growth factor for various central and peripheral neurons and has recei...
Programme: FP5-LIFE QUALITY
Record Number: 63674
Last updated on: 2005-04-12
GDNF promotes tubulogenesis of GFR-1-expressing MDCK cells by Src-mediated phosphorylation of MET receptor tyrosine kinase
We have identified the receptor tyrosine kinase Met –the receptor for hepatocyte growth factor (HGF)– as the p150 downstream signaling component for both RET-dependent and -independent GDNF signaling. We have found that GDNF can partially restore ureteric branching morphogenes...
Programme: FP5-LIFE QUALITY
Record Number: 38762
Last updated on: 2006-02-28
Structure of the GDNF receptor GFR1 and its GDNF binding surface
We have solved the 1.8 Å crystal structure of the GFR1 domain 3 and discovered a new protein fold. It is an all-alpha five-helix bundle stabilized by five disulfide bridges. The structure was used to model the homologous domain 2, the other half of the GDNF-binding fragment, a...
Programme: FP5-LIFE QUALITY
Record Number: 38764
Last updated on: 2006-02-28
European collaboration on craniofacial anomalies
ID: QLG1-CT-2000-01019
Start date: 2000-10-01, End date: 2004-12-31
This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for...
Programme: FP5-LIFE QUALITY
Record Number: 54578
Last updated on: 2005-04-12
N-syndecan as a novel receptor for GDNF
Syndecan-3 is a heparan sulphate proteoglycan (HSPG) that is profoundly expressed during brain development and maturation. We have found that GDNF interacts directly with syndecan-3 endogenously expressed by rat C6 glioma cell line. Affinity labelling of C6 cell with I125-GDNF...
Programme: FP5-LIFE QUALITY
Record Number: 38763
Last updated on: 2006-02-28
New therapeutic approaches to osteoporosis: targeting the osteoclast v-atpase
ID: QLG1-CT-2000-01801
Start date: 2000-12-01, End date: 2004-11-30
By harnessing the different skills of a multidisciplinary consortium, it is proposed to develop chemical and immunotherapeutic approaches directed towards inhibition of the osteoclast vacuolar ATPase. Specifically, this protein complex is responsible for the acidification proc...
Programme: FP5-LIFE QUALITY
Record Number: 54589
Last updated on: 2005-04-12
Study of the immunotoxicity of EBDTC and mixed pesticide exposure in agricultural (potato) workers in Finland
An epidemiological study of the immunotoxicity of EBDTC and mixed pesticide exposure in agricultural (potato) workers was performed in Finland. Exposure parameters and immune parameters were measured, and questionnaires were applied to the workers. A deterministic model based ...
Programme: FP5-LIFE QUALITY
Record Number: 38554
Last updated on: 2006-02-28
Toxicological evaluation of the immune function of pesticide workers
ID: QLK4-CT-2001-00211
Start date: 2002-01-01, End date: 2005-03-31
Most of the human population is exposed to pesticides, which are ubiquitous contaminants of the ecosystem. Little is known about long-term effects consequent to prolonged, low dose-exposure to these compounds. Some laboratory data are available suggesting that prolonged exposu...
Programme: FP5-LIFE QUALITY
Record Number: 64521
Last updated on: 2005-04-12
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