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Final Report Summary - DATAGENOM (Post-genomic datamining of enzymes for the synthesis of chiral pharmaceutical intermediates)
The key focus of the DATAGENOM project was on exploiting the recent explosive growth of genomic data that has been made available from the massive Deoxyribonucleic acid (DNA) sequencing programmes. As large-scale DNA sequencing of various life forms has become easier and less ...
Programme: FP6-LIFESCIHEALTH
Record Number: 51605
Last updated on: 2011-04-14
Final Report Summary - POLYGENE (Inherited risk of breast and prostate cancer)
The overall objective of POLYGENE was to identify inherited risk factors of two important cancers that have been shown to have a substantial genetic component, prostate cancer in men and breast cancer in women. The specific objectives of the project were: 1. Genome-wide ass...
Programme: FP6-LIFESCIHEALTH
Record Number: 47055
Last updated on: 2011-04-14
Strengthen and develop scientific and technological excellence in research and therapy of leukemia (CML, AML, ALL, CLL, MDS, CMPD) by integration of the leading national leukemia networks and their interdisciplinary partner groups in Europe
ID: 503216
Start date: 2004-01-01, End date: 2011-02-28
Leukemias are a challenge to society and a cost factor because of their frequency in all age groups. They also serve as a model for a variety of diseases and possess exemplary relevance for basic research and patient care. Leukemia research and therapy have achieved high stand...
Programme: FP6-LIFESCIHEALTH
Record Number: 75278
Last updated on: 2011-04-05
Comet assay and cell array for fast and efficient genotoxicity testing
ID: 37575
Start date: 2007-01-01, End date: 2009-12-31
A battery of reliable and validated in vitro assays is needed to test for genotoxic and cytotoxic effects of chemicals (as in the REACH programme) without resorting to animal experiments. The comet assay, a sensitive indicator of DNA damage, will be combined in this project wi...
Programme: FP6-LIFESCIHEALTH
Record Number: 85008
Last updated on: 2009-12-18
The Danubian Biobank Initiative - Towards Information-based Medicine
ID: 18822
Start date: 2006-01-01, End date: 2008-12-31
The association of aging disorders with the fast growing population group of over 65 years in the European population is an increasing challenge for the public health care systems in Europe. An important approach to cope with this task is the identification of relevant novel ...
Programme: FP6-LIFESCIHEALTH
Record Number: 81186
Last updated on: 2013-03-26
Genomics to combat resistance against antibiotics in community-acquired LRTI in Europe
ID: 518226
Start date: 2006-03-01, End date: 2011-08-31
GRACE is a Network of Excellence focusing on the complex and controversial field of community-acquired lower respiratory tract infections (LRTI), which is one of the leading reasons for seeking medical care. The promiscuous use of antibiotics to treatmen t of LRTI accounts for...
Programme: FP6-LIFESCIHEALTH
Record Number: 78765
Last updated on: 2012-08-10
Targeting newly discovered oxygen-sensing cascades for novel cancer treatments Biology, equipment, drug candidates.
ID: 502932
Start date: 2004-02-01, End date: 2009-01-31
The last decade's basic and clinical oncology research has revealed a number of so far unrecognised regulating responses (e.g. HIF-1) in cells exposed to hypoxia. These processes have been proven highly important for embryonic development and survival and seem to have a major ...
Programme: FP6-LIFESCIHEALTH
Record Number: 75264
Last updated on: 2009-04-28
Post-genomic datamining of enzymes for the synthesis of chiral pharmaceutical intermediates
ID: 503017
Start date: 2003-12-01, End date: 2006-11-30
Chirality is a key factor in the efficacy of many drugs and the production of single enantiomers of chiral intermediates has therefore become increasingly important. Biocatalysis offers high enantioselectivity and regioselectivity in chiral synthesis through enzyme-catalyzed r...
Programme: FP6-LIFESCIHEALTH
Record Number: 75267
Last updated on: 2009-12-23
Improved precision of nucleic acid based therapy of cystic fibrosis
ID: 5213
Start date: 2005-01-01, End date: 2008-06-30
The epithelial sodium channel (ENaC) is assumed to play a major role in the pathogenesis of chronic lung disease incystic fibrosis patients. Its natural regulation by the cystic fibrosis transmembrane conductance regulator (CFTR)appears to be compromised based on the impaired ...
Programme: FP6-LIFESCIHEALTH
Record Number: 74036
Last updated on: 2009-12-14
Mentoring of lifescihealth-multipliers in the accession candidate countries
ID: 512010
Start date: 2005-01-01, End date: 2006-12-31
Exploiting methodologies, developed by them in the IST-Mentor project, EU multipliers, with the help of local NCPs for LifeSciHealth, will identify and mentor candidate LifeSciHealth multipliers, in 11 ACCs - BG, CZ, CY, EE, LT, LV, PL, RO, SI, SK, TR. The se LifeSciHealth mul...
Programme: FP6-LIFESCIHEALTH
Record Number: 75466
Last updated on: 2009-12-14
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