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The materials and know-how generated by our group largely facilitate and speed up drug development and target evaluation by high-thruput screening with target-oriented engineered reporter cell lines. This approach is applicable to a large number of pharmacological questions an...
Programme: FP4-BIOMED 2
Record Number: 23189
Last updated on: 2001-02-22
The broad pharmacological profile of nociceptin, the endogenous neuropeptide agonist of the ORL1 receptor, points to a plethora of potential therapeutic applications, particularly in the treatment of pain, stress and anxiety. A molecular model of the complex formed between noc...
Programme: FP4-BIOMED 2
Record Number: 26764
Last updated on: 2001-07-30
Screening for ORL1 receptor ligands. A selective and quantitative radio-receptor assay has been set up. This assay is based upon the ability of a compound to compete with equilibrium binding of radiolabelled nociceptin in a crude membrane fraction from recombinant CHO cells ex...
Programme: FP4-BIOMED 2
Record Number: 26763
Last updated on: 2001-07-30
Rat hepatocytes have been cultured as primary cultures and incubated in the presence of various catechols. The hepatocytes have the advantage to express the whole set of drug metabolising enzymes, including the UDP-glucuronosyltransferases, sulfotransferases and catechol-O-met...
Programme: FP4-BIOMED 2
Record Number: 26753
Last updated on: 2001-07-30
By transfer of a curative transgene, we have achieved the full phenotypic reversion of primary keratinocytes of patients with a mild form of junctional epidermolysis bullosa (JEB) associated with genetic point mutations in the laminin beta3 gene. These findings confirm the fea...
Programme: FP4-BIOMED 2
Record Number: 26351
Last updated on: 2003-01-17
[REPORT SUMMARY] Amniodistention devices
Although the amnio-insufflator is technically satisfying, its clinical use is hampered by the observation that CO2 affects fetal acid-base status (reference 1). Recent observations have questioned the concern for fetal hypercapnia and acidosis (reference 2), but the research c...
Programme: FP4-BIOMED 2
Record Number: 23307
Last updated on: 1999-11-03
We have transferred purified anti-Mollerian hormone (AMH) and monoclonal antibodies developed in our laboratory to a commercial firm, Immunotech Coulters, which has commercialised an ELISA for human anti-Mollerian hormone which can be used for the assay of AMH in human serum a...
Programme: FP4-BIOMED 2
Record Number: 26752
Last updated on: 2001-07-30
Summary: Human cytochrome P450 isozymes that catalyze generation of hydroxylated metabolites from the NSAID diclofenac were studied using fully characterized human hepatic microsomes from a liver bank, isozyme-selective inhibitors, human hepatocytes and engineered cells expres...
Programme: FP4-BIOMED 2
Record Number: 23747
Last updated on: 2000-01-20
The molecular bases underlying the clinical observations that define the clinical variants of severe and mild junctional epidermolysis bullosa (JEB) have been clarified. The identification of new candidate genes in the clinical variants of JEB, and the identification of novel ...
Programme: FP4-BIOMED 2
Record Number: 26350
Last updated on: 2003-01-17
Dynein heavy chains are highly conserved from protozoa to human and by phylogenetic analysis, the evolutionary ancestry of these dynein heavy chain cDNA fragments was deduced. These dynein heavy chain cDNAs are highly transcribed in human tissues containing axonema such as tra...
Programme: FP4-BIOMED 2
Record Number: 25931
Last updated on: 2001-03-05
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