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Mechanisms of formation of ionising radiation-induced chromosomal aberrations: Impact of repair pathways and nuclear architecture
ID: FIGH-CT-1999-00011
Start date: 2000-02-01, End date: 2003-01-31
Chromosomal aberrations are efficiently induced by ionising radiation and contribute to a great extent to the development of cancer. Increased resolution of molecular cytogenetics along with the availability of cell lines and knockout mouse models sensitive to radiation, provi...
Programme: FP5-EAECTP C
Record Number: 52737
Last updated on: 2004-08-09
High-energy neutron detectors by fission reactions in Bi, Au, and Tantalum
The APAT group employs a stack formed by several different passive detectors (track detectors, bubble detectors, TLDs) and personal electronic dosimeters. By the proper choice of the detectors to be used, it is possible to obtain a stack respectively for the spectrometry of l...
Programme: FP5-EAECTP C
Record Number: 36061
Last updated on: 2005-04-12
Retrospective and prospective dosimetry of galactic and solar cosmic rays
Different passive detectors can be easily used for the assessment of the dose due to the galactic cosmic ray. By contrast, the assessment of the cumulative exposure to solar cosmic rays is relatively much more difficult. The possibility of exposure to solar flare radiation giv...
Programme: FP5-EAECTP C
Record Number: 36065
Last updated on: 2005-04-12
In-flight measurements of route doses by the ANPA stack
The data obtained with the ANPA stack on hundreds of repeated return long-haul flights on the routes Milan-Los Angeles, Milan-Tokyo and Rome Rio-de Janeiro have been used to study the reproducibility of the route dose at different phases of the solar cycle. These data have p...
Programme: FP5-EAECTP C
Record Number: 36072
Last updated on: 2005-04-12
European network for the consolidation of the integral system experimental databases for reactor thermal-hydraulic safety analysis
The programmatic objectives of the CERTA Thematic Network were primarily intended at establishing a consolidated framework for the preservation of reactor safety thermal-hydraulic databases acquired in European integral system test facilities and at providing data access/retri...
Programme: FP5-EAECTP C
Record Number: 30558
Last updated on: 2003-09-11
Rejoining and repair fidelity of DNA
Main results are: - Evolution of activities from previous contracts. - Importance of repair and influence of complexity of reparability for different radiations. - Differences between correct rejoining and misrepair. - Differences between low-dose rate and acute exposure versu...
Programme: FP5-EAECTP C
Record Number: 31438
Last updated on: 2003-12-18
Telomeres and telomerase in radio-sensitivity and gene amplification
Telomeres and telomerase play key roles in the maintenance of genome stability. Chiara Mondello, in collaboration with Elena Giulotto, has shown that in telomerase expressing cells, very short telomeres do not increase cellular and chromosomal radiosensitivity, as they do in t...
Programme: FP5-EAECTP C
Record Number: 44380
Last updated on: 2007-08-22
Double strand break repair functions and gene amplification
It is known that DNA-PKcs is a key protein for the repair of DSBs through the NHEJ pathway and that DSBs can initiate gene amplification. The results obtained by Elena Giulotto and Chiara Mondello indicate that in human cells an impairment in DNA-PKcs function increases the pr...
Programme: FP5-EAECTP C
Record Number: 44379
Last updated on: 2007-08-22
General guideline
[REPORT SUMMARY] General guideline
The consortium collated and analysed experience on the assessment of internal dose from incorporation monitoring data. A wide range of radionuclides was covered, with emphasis on the actinides (e.g. uranium, plutonium), fission products (e.g. caesium, strontium) and activation...
Programme: FP5-EAECTP C
Record Number: 39508
Last updated on: 2007-01-03
Megawatt pilot experiment- test
[PROJECT] MEGAPIE - Megawatt pilot experiment- test
ID: FIKW-CT-2001-00159
Start date: 2001-11-01, End date: 2004-10-31
Transmutation is considered a promising and feasible technology worldwide for significantly reducing the amount, and thereby, the long-term radiotoxicity of highly radioactive waste. Transmutation can be done in an Accelerator Driven System (ADS). A key component of such an AD...
Programme: FP5-EAECTP C
Record Number: 58637
Last updated on: 2003-04-01
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