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Development of early non-invasive biomarkers and means for the diagnosis and progression monitoring of pre-eclampsia and tailoring putative therapies
ID: 37244
Start date: 2006-12-01, End date: 2009-11-30
Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruptio...
Programme: FP6-LIFESCIHEALTH
Record Number: 84948
Last updated on: 2010-03-02
Advanced molecular tools for array-based analyses of genomes, transcriptomes, proteomes, and cells
ID: 503155
Start date: 2004-01-01, End date: 2007-06-30
The recording of complete genome sequences provides for the first time opportunities to comprehensively characterize the flow of information from genetic variation at the DNA level, over messages expressed as RNA, and on to their protein products, and to functions of the cell....
Programme: FP6-LIFESCIHEALTH
Record Number: 75275
Last updated on: 2010-11-17
Integrated genomics, clinical research and care in hypertension
ID: 37093
Start date: 2006-11-01, End date: 2011-01-31
The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics,...
Programme: FP6-LIFESCIHEALTH
Record Number: 84934
Last updated on: 2013-03-26
Identification of genetic roots of coronary artery disease by combining stepwise genome wide association studies with transcriptomic and functional genomic investigation of relevant genetic variants
ID: 37593
Start date: 2006-10-01, End date: 2011-03-31
The heritability of coronary artery disease (CAD) and myocardial infarction (MI) has been unequivocally demonstrated. However, traditional technology, for example based on investigation of candidate genes, or linkage analysis, has failed to elucidate the genetic roots of the N...
Programme: FP6-LIFESCIHEALTH
Record Number: 85010
Last updated on: 2013-03-26
Epigenetic treatment of neoplastic disease
ID: 518417
Start date: 2005-11-01, End date: 2011-04-30
Chromatin is epigenetically modified to regulate gene expression. Upstream signals induce complex patterns of enzyme-catalyzed modifications of DNA and histones, key protein components of chromatin. These epigenetic modifications create docking sites for other regulators and f...
Programme: FP6-LIFESCIHEALTH
Record Number: 78780
Last updated on: 2011-05-30
ENFIN - an experimental network for functional integration
ID: 518254
Start date: 2005-11-15, End date: 2011-05-14
We propose to form a Network of Excellence in the area of bioinformatics to provide a Europe-wide integration of computational approaches in systems biology. This network will be focused on the development and critical assessment of computational approaches in this area, but u...
Programme: FP6-LIFESCIHEALTH
Record Number: 75903
Last updated on: 2013-03-26
Clinical Neuroproteomics of Neurodegenerative Diseases
ID: 37950
Start date: 2007-04-01, End date: 2010-09-30
Alzheimer's dementia (AD) is one of the most common brain diseases in the elderly. Dementias pose a major health problem in European countries, with currently 5.7 million affected dementia patients in the EU25. Currently no curative therapies are available for these dementias,...
Programme: FP6-LIFESCIHEALTH
Record Number: 100542
Last updated on: 2011-09-26
RNA Interference Technology as Human Therapeutic Tool
ID: 5276
Start date: 2005-01-01, End date: 2009-06-30
The RIGHT project aims at exploiting the vast potential of RNA interference (RNAi) for human therapy, based on an advanced understanding of the underlying mechanisms. Rational and selective approaches will be taken to generate efficient RNAi reagents, and strategies will be de...
Programme: FP6-LIFESCIHEALTH
Record Number: 74045
Last updated on: 2013-03-26
Inhibition of stress activated protein kinase signalling as a therapeutic strategy against excitotoxicity
ID: 5310
Start date: 2005-01-01, End date: 2008-06-30
Excitotoxicity (EXC), neuronal death from excessive stimulation, contributes to a plethora of neurodegenerative conditions including cerebral ischemia and seizure-induced death. Stress activated protein kinases (SAPKs) of the JNK and p38 families have been identified as novel ...
Programme: FP6-LIFESCIHEALTH
Record Number: 74046
Last updated on: 2013-03-26
Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome
ID: 5272
Start date: 2005-01-01, End date: 2009-12-31
The European Union, like the rest of the world, is faced with an epidemic of the related chronic conditions, Type 2 diabetes, obesity and the metabolic syndrome. Unless steps are taken to alleviate this crisis, the cost of treating the long-term consequences of these condition...
Programme: FP6-LIFESCIHEALTH
Record Number: 74044
Last updated on: 2010-10-20
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