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Identification of novel HIV-1 epitopes as vaccine candidates
ID: 12168
Start date: 2005-08-01, End date: 2007-10-31
The aim of this project is to select peptide epitopes that mimic neutralization sensitive domains of HIV-1 envelope and may function as candidate HIV-1 vaccines. To date, efforts to develop a truly prophylactic HIV-1 vaccine have been hindered by difficult y in identifying imm...
Record Number: 74821
Last updated on: 2008-07-21
Application and process optimization of human stem cells for myocardium reapair
ID: 502988
Start date: 2004-02-01, End date: 2008-01-31
Myocardial infarction (Ml) is an irreversible injury where sudden interruption of blood flow caused by the occlusion of an artery leads quickly to cardiac myocytes death, loss of tissue and scar formation. Since the self- renewal ability of adult cardiac myocytes is limited, t...
Record Number: 75266
Last updated on: 2009-12-23
Development of early non-invasive biomarkers and means for the diagnosis and progression monitoring of pre-eclampsia and tailoring putative therapies
ID: 37244
Start date: 2006-12-01, End date: 2009-11-30
Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruptio...
Record Number: 84948
Last updated on: 2010-03-02
Placental Growth Factor (PlGF): new diagnostic and therapeutic applications in cardiovascular disease
ID: 37254
Start date: 2007-01-01, End date: 2009-03-31
The proposed Strep evaluates the potential of PlGF as a pharmaceutical for major chronic progressive cardiac disorders (ischemic heart disease, heart failure and arterial insufficiency (intermittent claudication and critical limb ischemia)) and as a biomarker for cardiovascula...
Record Number: 84951
Last updated on: 2013-03-26
Integrated genomics, clinical research and care in hypertension
ID: 37093
Start date: 2006-11-01, End date: 2011-01-31
The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics,...
Record Number: 84934
Last updated on: 2013-03-26
Final Report Summary - INGENIOUS HYPERCARE (Integrated Genomics, Clinical Research and Care in Hypertension)
A better prevention of hypertension and hypertension-related cardiovascular events is an essential public health goal in Europe, where cardiovascular diseases are the major cause of mortality and morbidity. Despite the widely shared opinion that hypertension has an important h...
Record Number: 53036
Last updated on: 2012-05-24
Identification of genetic roots of coronary artery disease by combining stepwise genome wide association studies with transcriptomic and functional genomic investigation of relevant genetic variants
ID: 37593
Start date: 2006-10-01, End date: 2011-03-31
The heritability of coronary artery disease (CAD) and myocardial infarction (MI) has been unequivocally demonstrated. However, traditional technology, for example based on investigation of candidate genes, or linkage analysis, has failed to elucidate the genetic roots of the N...
Record Number: 85010
Last updated on: 2013-03-26
Development of New Drugs for the Treatment of Malaria
ID: 18834
Start date: 2005-12-01, End date: 2011-05-31
Leading groups of malaria researchers will integrate their expertise in malaria biology and drug development to exploit new scientific and political opportunities to secure the development of a portfolio of viable novel AntiMalarial drugs. New chemical entities will be commerc...
Record Number: 78405
Last updated on: 2011-12-20
Genetic and environmental determinants of melanoma: translation into behavioural change
ID: 18702
Start date: 2005-12-01, End date: 2011-05-31
GenoMEL, formerly known as the Melanoma Genetics Consortium, has focused on the identification of familial high penetrance melanoma genes. The joint programme of research has been very successful in the identification of susceptibility genes and developing joint data collectio...
Record Number: 84807
Last updated on: 2011-07-26
Epigenetic treatment of neoplastic disease
ID: 518417
Start date: 2005-11-01, End date: 2011-04-30
Chromatin is epigenetically modified to regulate gene expression. Upstream signals induce complex patterns of enzyme-catalyzed modifications of DNA and histones, key protein components of chromatin. These epigenetic modifications create docking sites for other regulators and f...
Record Number: 78780
Last updated on: 2011-05-30
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List retrieved on: 2017-03-25
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