Results 1 - 10 of 314
[PROJECT] PASSAM - Passive and Active Systems on Severe Accident source term Mitigation
ID: 323217
Start date: 2013-01-01, End date: 2016-12-31
In case of a severe accident in a Nuclear Power Plant (NPP) fission products are released from the degraded fuel and might reach the environment if their confinement is lost and/or bypassed. Given the high radio-toxic nature of fission products for environment and population,...
Programme: FP7-EURATOM-FISSION
Record Number: 106448
Last updated on: 2017-02-21
[REPORT SUMMARY] Radio-sensitivity, DNA repair and biology of telomeres in radiosensitive individuals
Fanconi anemia (FA) patients show accelerated telomere shortening. In order to get further insights in to the role of the FA pathway in telomere biology, Jordi Surralles and his team studied whether FANCD2, a key downstream factor in this pathway, binds to telomeres. They inve...
Programme: FP5-EAECTP C
Record Number: 44382
Last updated on: 2007-08-22
[REPORT SUMMARY] Telomere and whole genome tri-dimensional reconstruction of inter-phase nuclei architecture in response to ionising radiation
Jordi Surralles' objective was to study the architecture of the inter-phase nuclei from the telomere perspective and it response to ionising radiation. He found that telomeres have a defined 3D distribution pattern inside the interphase nucleus that is independent of histone H...
Programme: FP5-EAECTP C
Record Number: 44383
Last updated on: 2007-08-22
[REPORT SUMMARY] Mouse models of telomerase overexpression
In the past, Maria Blasco and her team (partner CNIO) have shown that the telomerase reverse transcriptase component (Tert) may favour growth and survival independently of telomere length maintenance. They have generated two mouse models that over-express Tert under the kerati...
Programme: FP5-EAECTP C
Record Number: 44388
Last updated on: 2007-08-22
[REPORT SUMMARY] Telomeres modulate radiation response in vitro and in vivo - Vegetable intake prevents excessive telomere shortening
Mouse studies in the frame of this and previous EU project have determined that telomere length modulates radiosensitivity. Thus, telomerase KO mice with short telomeres (late generation) are more sensitive that telomere KO mice with long telomeres (earlier generation KO mice)...
Programme: FP5-EAECTP C
Record Number: 44384
Last updated on: 2007-08-22
[REPORT SUMMARY] Genomic instability and telomere length, radiation sensitivity of human mammary epithelial cells in culture
Human mammary epithelial cells derived from normal breast tissue from three women subjected to spontaneous reduction were analysed. These cells may spontaneously overcome the normal proliferation limits by loosing expression of p16 protein. The karyotype evolution of HMECs was...
Programme: FP5-EAECTP C
Record Number: 44381
Last updated on: 2007-08-22
[PROJECT] TELOSENS - Telomeres and radiosensitivity of individuals
ID: FIGH-CT-2002-00217
Start date: 2003-01-01, End date: 2005-12-31
Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that ...
Programme: FP5-EAECTP C
Record Number: 67972
Last updated on: 2003-04-01
[REPORT SUMMARY] Role of DNA repair proteins in telomere function
To further define the role of DNA repair proteins in telomere function and telomere-driven radiosensitivity, Maria Blasco and her team (partner CNIO) has studied cells from mice deficient for the DNA repair proteins Ku86, DNA-PKcs, and PARP-1. Previous work of partner CNIO sho...
Programme: FP5-EAECTP C
Record Number: 44386
Last updated on: 2007-08-22
[REPORT SUMMARY] The Halosperm® kit to determine sperm DNA fragmentation
A simple and reliable procedure is now available, as a kit, to determine sperm DNA fragmentation. The integrity of sperm DNA is indeed being recognized as a new parameter of semen quality and a potential fertility predictor. However, it was not so far assessed as a routine par...
Programme: FP5-EAECTP C
Record Number: 44376
Last updated on: 2007-08-22
[REPORT SUMMARY] Novel mechanisms of telomere maintenance
During the progression of Telosens work, novel mechanisms of telomere maintenance were identified. Previous work of Maria Blasco and her team (partner CNIO) provide evidence for the implication of epigenetic mechanisms in the regulation of mammalian telomere length and functio...
Programme: FP5-EAECTP C
Record Number: 44387
Last updated on: 2007-08-22
List retrieved on: 2017-08-02
