Results 1 - 10 of 397
[REPORT SUMMARY] Link between telomere maintenance & DNA damage response mechanisms, and their role of individual radio-sensitivity. Insights on action of BRCA1 gene
Telomeres are physical ends of chromosomes responsible for chromosomal end protection. There is a strong inter-dependence between telomere maintenance and cellular mechanisms that regulate DNA damage response. At least 17 mammalian genes involved in DNA damage response have, s...
Programme: FP5-EAECTP C
Record Number: 44378
Last updated on: 2007-08-22
[PROJECT] TELOSENS - Telomeres and radiosensitivity of individuals
ID: FIGH-CT-2002-00217
Start date: 2003-01-01, End date: 2005-12-31
Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that ...
Programme: FP5-EAECTP C
Record Number: 67972
Last updated on: 2003-04-01
[PROJECT] INTERSTANDER - The role of intercellular communication and DNA double strand breaks in the induction of bystander effects
ID: FIGH-CT-2002-00218
Start date: 2003-03-01, End date: 2006-03-01
The biological processes mediating bystander responses are incompletely understood despite the relevance of this phenomenon to radiation protection and radiation therapy. The present proposal contributes to the elucidation of the mechanisms underlying bystander effects by eval...
Programme: FP5-EAECTP C
Record Number: 69008
Last updated on: 2003-04-01
[PROJECT] NANET - Network to review natural analogue studies and their applications to repository safety assessment and public communication
ID: FIKW-CT-2002-20204
Start date: 2003-01-01, End date: 2004-12-31
The aim of this project is to promote a more considered use of natural analogues in safety assessment and public communication. This will be achieved by a critical review of traditional analogue studies, such as investigations of radionuclide transport around uranium ore bodie...
Programme: FP5-EAECTP C
Record Number: 67692
Last updated on: 2003-04-01
[PROJECT] NON-DSB LESIONS - Radiation specific DNA non-double strand break lesions: repair mechanisms and biological effects
ID: FIGH-CT-2002-00207
Start date: 2003-01-01, End date: 2004-12-31
Ionising radiation induces a plethora of DNA non-double strand break lesions such as oxidised bases, a basic sites and single strand breaks. Strong evidence exists that ionising radiation induces, besides isolated DNA lesions; a unique form o f DNA damage termed clustered dama...
Programme: FP5-EAECTP C
Record Number: 69500
Last updated on: 2003-04-24
[PROJECT] CHILD-THYR - Risk of thyroid cancer following exposure to I-131 early in life
ID: FIGH-CT-2002-20206
Start date: 2002-11-01, End date: 2004-10-31
This proposal if for bringing together formally data from a number of recently and soon to be completed epidemiological studies of thyroid cancer in relation toI-131 exposure in childhood and adolescence. The studies have been carried out in Belarus, Russia, French Polynesia, ...
Programme: FP5-EAECTP C
Record Number: 65184
Last updated on: 2003-04-01
[PROJECT] ACTINET - Establishment of a Network of Excellence for Actinide Science
ID: FIR1-CT-2002-20211
Start date: 2002-11-01, End date: 2004-10-31
The proposed project is to prepare a Europe-wide network structure for advanced research on 'Actinide Sciences' for the further development of nuclear fuel cycle, including the safe disposal of nuclear waste. The network is envisaged to facilitate the coordination and utilizat...
Programme: FP5-EAECTP C
Record Number: 65144
Last updated on: 2003-04-01
[PROJECT] GENEPI - ENTB - Genetic pathways for the prediction of the effects of irradiation - European normal and tumour tissue bank
ID: FIR1-CT-2002-20213
Start date: 2002-11-01, End date: 2005-10-31
In synergy with RTD Project GENEPI 1, a tissue bank, including lymphocytes and skin biopsies and a database will be created as essential infrastructure for present and future genetic research in the field of radiation protection and health. From normal tissues obtained from up...
Programme: FP5-EAECTP C
Record Number: 65196
Last updated on: 2003-04-01
[PROJECT] GEMRATE - Genetic factors predisposing to radiation induction of mutation during early gestation: the role of DNA repair and cell cycle control
ID: FIGH-CT-2002-00210
Start date: 2002-11-01, End date: 2005-10-31
Recent reports in the mouse indicate considerable radiation sensitivity of particularly the early zygote and the post implantation gastrula stages. Data on the chromatin stability of human sperm and chromosome stability of pre implantation embryos point at the genetic vulnerab...
Programme: FP5-EAECTP C
Record Number: 64861
Last updated on: 2003-04-01
[PROJECT] GENRAD-T - Genetics of predisposition to radiation-induced cancer of the thyroid
ID: FIGH-CT-2002-00208
Start date: 2002-11-01, End date: 2005-04-30
Carcinoma of the thyroid is a serious public health problem in populations at risk of exposure to radio nuclides accumulating in thyroid tissue. However, due to genetically determined differences in individual susceptibility to ionising radiation, simple dose-response relation...
Programme: FP5-EAECTP C
Record Number: 64905
Last updated on: 2003-04-01
List retrieved on: 2017-08-02
