Results 31 - 40 of 2310
[RESULT IN BRIEF] Associazione tra telomeri e proteine di riparazione del DNA
Ricercatori europei hanno ulteriormente spiegato il ruolo dei telomeri e delle proteine di riparazione del DNA nel telomero in riferimento alla radiosensibilità.
Programme: FP5-EAECTP C
Record Number: 85003
Last updated on: 2009-06-22
[RESULT IN BRIEF] Asocjacja telomerowa z białkami naprawczymi DNA
Europejscy naukowcy dokładniej wyjaśnili rolę białek telomerowych i naprawczych DNA w promienioczułości związanej z telomerami.
Programme: FP5-EAECTP C
Record Number: 85003
Last updated on: 2013-07-05
[REPORT SUMMARY] Role of DNA repair proteins in telomere function
To further define the role of DNA repair proteins in telomere function and telomere-driven radiosensitivity, Maria Blasco and her team (partner CNIO) has studied cells from mice deficient for the DNA repair proteins Ku86, DNA-PKcs, and PARP-1. Previous work of partner CNIO sho...
Programme: FP5-EAECTP C
Record Number: 44386
Last updated on: 2007-08-22
[REPORT SUMMARY] The Halosperm® kit to determine sperm DNA fragmentation
A simple and reliable procedure is now available, as a kit, to determine sperm DNA fragmentation. The integrity of sperm DNA is indeed being recognized as a new parameter of semen quality and a potential fertility predictor. However, it was not so far assessed as a routine par...
Programme: FP5-EAECTP C
Record Number: 44376
Last updated on: 2007-08-22
[REPORT SUMMARY] Cytogenetic experiments failed to detect clear evidence for a negative bystander response in human lymphocytes cultured with irradiated cells
Irradiated Go lymphocytes were fused to exponentially growing CHO cells and cultured for up to 30h. In the hybrid cells, lymphocyte PCCs were induced when CHO entered mitosis. Cells were harvested at various times after cell fusion using shake off and subsequently chromosome p...
Programme: FP5-EAECTP C
Record Number: 44729
Last updated on: 2007-12-12
[REPORT SUMMARY] Novel mechanisms of telomere maintenance
During the progression of Telosens work, novel mechanisms of telomere maintenance were identified. Previous work of Maria Blasco and her team (partner CNIO) provide evidence for the implication of epigenetic mechanisms in the regulation of mammalian telomere length and functio...
Programme: FP5-EAECTP C
Record Number: 44387
Last updated on: 2007-08-22
[REPORT SUMMARY] No negative bystander effects were observed for human cells (HSF) exposed to either 4.5MeV alpha particles or 10MeV protons using a microbeam
In order to study the parameter of LET and cell type on the development of bystander effects using cell survival as endpoint, we carried out experiments with primary human skin fibroblasts (HSF2). Using 4.5MeV alpha particles (LET = 100keV/µm) we were unable to measure bystand...
Programme: FP5-EAECTP C
Record Number: 44728
Last updated on: 2007-12-12
[RESULT IN BRIEF] Voraussetzungen für den Bystander-Effekt
Die Wirkung von Strahlung ist nicht nur auf die direkt bestrahlten Zellen begrenzt. Forscher untersuchten den so genannten Bystander-Effekt und dessen Bedeutung für den Strahlenschutz und die Strahlentherapie.
Programme: FP5-EAECTP C
Record Number: 84786
Last updated on: 2009-02-09
[RESULT IN BRIEF] Circunstancias necesarias para que se produzca el efecto espectador
Las consecuencias de la radiación no siempre se limitan a las células a las que el bombardeo alcanza directamente. Un grupo de investigadores de un proyecto comunitario ha investigado el llamado «efecto espectador» a fin de determinar su importancia tanto en la protección contra las radiaciones como en la radioterapia.
Programme: FP5-EAECTP C
Record Number: 84786
Last updated on: 2009-02-09
[REPORT SUMMARY] Impact of telomere dysfunction on the cellular and organismal response to radiation and genotoxic agents
In the past, Maria Blasco and her team (partner CNIO) have shown that mice with critically short telomeres are highly sensitive to ionising radiation, i.e. show increased chromosomal instability upon gamma-irradiation. More recent results from a close collaboration between par...
Programme: FP5-EAECTP C
Record Number: 44385
Last updated on: 2007-08-22
List retrieved on: 2017-08-02
