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Exploring the Future of Global Food and Nutrition Security
ID: 290693
Start date: 2012-03-01, End date: 2017-02-28
One of the biggest challenges facing global society today is the widespread and growing presence of hunger and food insecurity. Given that the lead time for some social and technological solutions is long, a long-term framework on global food and nutrition security (FNS) is r...
Programme: FP7-SSH
Record Number: 102690
Last updated on: 2017-04-03
A reporter gene-based bioassay to replace animal testing for measuring the pharmacological potency of glucocorticoids and their metabolites or derivatives
Synthetic glucocorticoids belong to the most frequently administered drugs in livestock production. These synthetic hormones are employed for therapeutic purposes against inflammatory reactions, disorders of the musculoskeletal system, bovine ketosis and many other diseases of...
Programme: FP5-LIFE QUALITY
Record Number: 36245
Last updated on: 2005-04-12
Prototype of a flow cell for particle structuring
The flow cell for particle generating and structuring of such particles in non-equilibrium shapes consists out of three major unit-operations: Sizing, Deformation and Gelling of the dispersed phase that is injected into a co-flowing continuous phase. Due to optimised tuning of...
Programme: FP5-LIFE QUALITY
Record Number: 36306
Last updated on: 2005-04-12
Role of oxidative stress in ochratoxin A-toxicity in vivo and mechanism of ochratoxin A toxicity in vitro
Biomarkers of oxidative stress have been analysed. The stress response was inconsistent regarding the different parameters however, a striking effect on the inducible nitric oxide synthase (iNOS) was observed in cell cultures correlated with a significant increase in protein n...
Programme: FP5-LIFE QUALITY
Record Number: 35548
Last updated on: 2005-02-02
Interference with thyroid hormone (T3) action as a possible mechanism for ochratoxin A toxicity
In aggregating brain cell cultures, 2-20 nM OTA elicited cell type-specific effects, while at higher concentrations general cytotoxicity was observed. Measurements at the mRNA level using real-time RT-PCR showed that 10nM OTA rapidly and significantly upregulated the inducible...
Programme: FP5-LIFE QUALITY
Record Number: 35553
Last updated on: 2005-02-02
New design of microfabricated optical cells
Microfabricated optical cells reported for fluorescence based analysis generally offer an optical path length limited to the substrate thickness, i.e. a reduced sample volume. Larger volume are highly desirable to increase the overall analysis sensitivity. The proposed optical...
Programme: FP5-LIFE QUALITY
Record Number: 30004
Last updated on: 2003-07-05
Collection of guidelines and strategies for allergen mangement
A collection of guidelines for allergen management including analytical methods for measuring allergen traces in food and a gap analysis in form of a development of a list of issues which need to be addressed and solved in the future to improve current allergen management stra...
Programme: FP5-LIFE QUALITY
Record Number: 44166
Last updated on: 2007-06-18
Intermediates in the reaction of iron(II) with hydrogen peroxide
The reaction of iron(II) with hydrogen peroxide is normally studied by stopped-flow spectrophotometry. Given a mixing time of at best 2 ms, it is possible that the reaction proceeds via an ironoxo(IV) intermediate that decays within the mixing time. With the pulse radiolyis te...
Programme: FP5-LIFE QUALITY
Record Number: 40880
Last updated on: 2006-08-01
Mechanism of S-nitrosothiol decomposition
Aside from the reaction of iron(II) complexes with peroxides that yield reactive radicals, the Fenton reaction, iron also catalyzes the decompositions of nitrosothiols that play a role in the homostasis of vascular tension. The mechanisms of S-nitrosothiol transformation int...
Programme: FP5-LIFE QUALITY
Record Number: 40877
Last updated on: 2006-08-01
Redox-cycling of iron complexes and inhibition by nitrogen monoxide
The toxicity of iron is believed to originate from the reaction of a Fe(II) complex with hydrogen peroxide that produces HO". NO" slows the rate of the oxidation (as studied by stopped?flow spectrophotometry) of Fe(II) bound to citrate, atp and various aminopolycarboxylates by...
Programme: FP5-LIFE QUALITY
Record Number: 40878
Last updated on: 2006-08-01
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