Results 1 - 10 of 3934
[PROJECT] MITIN - INTEGRATION OF THE SYSTEM MODELS OF INSULIN SIGNALLING AND OF MITOCHONDRIAL FUNCTION AND ITS APPLICATION IN THE STUDY OF COMPLEX DISEASES
ID: 223450
Start date: 2008-11-01, End date: 2011-10-31
A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of...
Programme: FP7-HEALTH
Record Number: 88487
Last updated on: 2017-05-29
ID: 200923
Start date: 2008-04-01, End date: 2011-09-30
The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cas...
Programme: FP7-HEALTH
Record Number: 88157
Last updated on: 2017-05-29
[PROJECT] OPTIMUNISE - Optimising the impact and cost-effectiveness of child health intervention programmes of vaccines and micronutrients in low-income countries
ID: 261375
Start date: 2011-03-01, End date: 2016-08-31
International child health programmes in low-income countries are justified in term of their impact on child survival. However, the effect estimates are usually calculated from performance indicators and assumptions about efficacy based on small-scale target-specific studies....
Programme: FP7-HEALTH
Record Number: 98247
Last updated on: 2017-05-26
[PROJECT] EUROCANPLATFORM - A European Platform for Translational Cancer Research
ID: 260791
Start date: 2011-01-01, End date: 2016-12-31
Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer r...
Programme: FP7-HEALTH
Record Number: 97701
Last updated on: 2017-05-29
[PROJECT] RATHER - Rational Therapy for Breast Cancer: Individualized Treatment for Difficult-to-Treat Breast Cancer Subtypes
ID: 258967
Start date: 2011-01-01, End date: 2018-06-30
Cancer genotyping has identified a number of correlations between mutations in specific genes and responses to targeted anti-cancer drugs, with many mutations occurring in kinases or downstream signaling components. While there are several ongoing large-scale genome re-sequen...
Programme: FP7-HEALTH
Record Number: 97660
Last updated on: 2017-07-16
[REPORT SUMMARY] Link between telomere maintenance & DNA damage response mechanisms, and their role of individual radio-sensitivity. Insights on action of BRCA1 gene
Telomeres are physical ends of chromosomes responsible for chromosomal end protection. There is a strong inter-dependence between telomere maintenance and cellular mechanisms that regulate DNA damage response. At least 17 mammalian genes involved in DNA damage response have, s...
Programme: FP5-EAECTP C
Record Number: 44378
Last updated on: 2007-08-22
[PROJECT] TELOSENS - Telomeres and radiosensitivity of individuals
ID: FIGH-CT-2002-00217
Start date: 2003-01-01, End date: 2005-12-31
Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that ...
Programme: FP5-EAECTP C
Record Number: 67972
Last updated on: 2003-04-01
[PROJECT] INTERSTANDER - The role of intercellular communication and DNA double strand breaks in the induction of bystander effects
ID: FIGH-CT-2002-00218
Start date: 2003-03-01, End date: 2006-03-01
The biological processes mediating bystander responses are incompletely understood despite the relevance of this phenomenon to radiation protection and radiation therapy. The present proposal contributes to the elucidation of the mechanisms underlying bystander effects by eval...
Programme: FP5-EAECTP C
Record Number: 69008
Last updated on: 2003-04-01
[PROJECT] NON-DSB LESIONS - Radiation specific DNA non-double strand break lesions: repair mechanisms and biological effects
ID: FIGH-CT-2002-00207
Start date: 2003-01-01, End date: 2004-12-31
Ionising radiation induces a plethora of DNA non-double strand break lesions such as oxidised bases, a basic sites and single strand breaks. Strong evidence exists that ionising radiation induces, besides isolated DNA lesions; a unique form o f DNA damage termed clustered dama...
Programme: FP5-EAECTP C
Record Number: 69500
Last updated on: 2003-04-24
[PROJECT] CHILD-THYR - Risk of thyroid cancer following exposure to I-131 early in life
ID: FIGH-CT-2002-20206
Start date: 2002-11-01, End date: 2004-10-31
This proposal if for bringing together formally data from a number of recently and soon to be completed epidemiological studies of thyroid cancer in relation toI-131 exposure in childhood and adolescence. The studies have been carried out in Belarus, Russia, French Polynesia, ...
Programme: FP5-EAECTP C
Record Number: 65184
Last updated on: 2003-04-01
List retrieved on: 2017-08-02
