Results 41 - 50 of 19448
As a result of the rapidly growing human population, mankind faces the enormous challenge to increase agricultural productivity while decreasing our ecological footprint in a changing climate. Plants are continuously threatened by a multitude of pathogens and pests, resulting...
Programme: FP7-IDEAS-ERC
Record Number: 201450
Last updated on: 2017-07-24
[PROJECT] PLANTIMMUSYS - The Plant Immune System: a multidisciplinary approach to uncover how plants simultaneously deal with beneficial and parasitic organisms to maximize profits and protection
ID: 269072
Start date: 2011-03-01, End date: 2017-02-28
In nature, plants live in complex environments in which they are attacked by a multitude of pathogens and pests. In agriculture this leads to tremendous annual crop losses, representing a value of over 450 billion worldwide. Beneficial associations between plants and other or...
Programme: FP7-IDEAS-ERC
Record Number: 98059
Last updated on: 2017-05-26
[PROJECT] GLYCOTREAT - Novel vaccine generation for the treatment of cancer. A glyco-nanomedial approach instructing T cells
ID: 339977
Start date: 2014-02-01, End date: 2019-01-31
There is an urgent need to develop vaccines for the induction of CD8+ T-cell immunity to treat cancer and infectious diseases. Dendritic Cells (DC) have shown potential to induce antigen specific CD8+ T-cell responses with the help of CD4+ T cells, yet the efficacy by which t...
Programme: FP7-IDEAS-ERC
Record Number: 192378
Last updated on: 2017-02-27
[REPORT SUMMARY] Periodic Report Summary 2 - GLYCOTREAT (Novel vaccine generation for the treatment of cancer. A glyco-nanomedial approach instructing T cells)
The Glycotreat project aims to develop new glycan based nanomedicines to target to DC for the induction of powerful T-cell responses to treat cancer. In this project we focus on two types of cancer: one induced by viruses, and the other with a focus on self-antigen melanoma...
Programme: FP7-IDEAS-ERC
Record Number: 201447
Last updated on: 2017-07-24
[PROJECT] OMVAC - Outer Membrane Vesicles (OMVs) from “Vaccinobacter”: A Synthetic Biology approach for effective vaccines against infectious diseases and cancer
ID: 340915
Start date: 2014-06-01, End date: 2019-05-31
This proposal intends to apply Synthetic Biology to create a new bacterial species, Vaccinobacter, devoted to the production of multivalent, highly effective vaccines. The project originates from the evidence that Outer membrane Vesicles (OMVs) naturally produced by all Gram-...
Programme: FP7-IDEAS-ERC
Record Number: 188508
Last updated on: 2016-11-28
Executive Summary The main objective of the OMVac project is to apply Synthetic Biology to create a new bacterial species, Vaccinobacter, devoted to the production of multivalent, highly effective vaccines against infectious diseases and cancer. The project is organized in...
Programme: FP7-IDEAS-ERC
Record Number: 201444
Last updated on: 2017-07-24
[REPORT SUMMARY] Periodic Report Summary 2 - HIV LTR G-4 (G-quadruplexes in the HIV-1 genome: novel targets for the development of selective antiviral drugs)
Screening In the first 30 months of the project, we have found and developed four small molecules that display anti-HIV-1 activity: one G-quadruplex (G4) ligand that inhibits HIV-1 with effective concentration (EC50) in the low micromolar range. To improve selectivity we have...
Programme: FP7-IDEAS-ERC
Record Number: 201441
Last updated on: 2017-07-24
[PROJECT] HIV LTR G-4 - G-quadruplexes in the HIV-1 genome: novel targets for the development of selective antiviral drugs
ID: 615879
Start date: 2014-05-01, End date: 2019-04-30
G-quadruplexes (G-4) are polymorphic nucleic acid structures identified in gene promoters where they act as transcription regulators. G-4s have been found in eukaryotic and prokaryotic organisms, while very little information is available on viruses. The applicant research gr...
Programme: FP7-IDEAS-ERC
Record Number: 188677
Last updated on: 2016-02-15
[PROJECT] Danger ATP - Regulation of inflammatory response by extracellular ATP and P2X7 receptor signalling: through and beyond the inflammasome
ID: 614578
Start date: 2014-09-01, End date: 2019-08-31
Inflammatory diseases affect over 80 million people worldwide and accompany many diseases of industrialized countries, being the majority of them infection-free conditions. There are few efficient anti-inflammatory drugs to treat chronic inflammation and thus, there is an urg...
Programme: FP7-IDEAS-ERC
Record Number: 192054
Last updated on: 2016-03-31
Adenosine triphosphate (ATP) is the molecule in charge to transport the chemical energy of the cell and maintain cellular metabolism. When a tissue is damaged, its cells release their intracellular content, and when ATP reaches high extracellular concentration, it signals to...
Programme: FP7-IDEAS-ERC
Record Number: 201432
Last updated on: 2017-07-24
List retrieved on: 2017-08-02
