Results 1 - 10 of 283
[REPORT SUMMARY] Pathogenesis of membrane damage in Duchenne Muscular Dystrophy (DMD)
In healthy patients dystrophin is localised just under the cell
membrane. It is absent in the Duchenne patient. The pathogenesis of
the disease is unknown. Since the discovery and cloning of the
dystrophin gene, potential gene therapy is the object of intense
research. The gro...
Programme: FP4-BIOMED 2
Record Number: 23199
Last updated on: 1999-10-04
[REPORT SUMMARY] Low energy laser irradiation promotes skeletal muscle regeneration
Low-energy laser (He-Ne) irradiation (LELI) was found to promote skeletal muscle regeneration in vivo. LELI has a direct effect on myogenic cells, since the same response (delayed differentiation and enhanced proliferation) was obtained in vitro upon treatment of primary rat s...
Programme: FP4-BIOMED 2
Record Number: 26766
Last updated on: 2001-07-30
[REPORT SUMMARY] A humanised mouse model for multiple sclerosis
A new mouse model has been established that is useful as a model for multiple sclerosis. The mouse contains the following genes from humans; the human class II genes DRA and DRB, the human CD4 and a human T cell receptor (TCRA and TCRB) specific for a peptide derived from myel...
Programme: FP4-BIOMED 2
Record Number: 26347
Last updated on: 2003-01-17
By transfer of a curative transgene, we have achieved the full phenotypic reversion of primary keratinocytes of patients with a mild form of junctional epidermolysis bullosa (JEB) associated with genetic point mutations in the laminin beta3 gene. These findings confirm the fea...
Programme: FP4-BIOMED 2
Record Number: 26351
Last updated on: 2003-01-17
[REPORT SUMMARY] ELISA for anti-Mollerian hormone (AMH/MIS)
We have transferred purified anti-Mollerian hormone (AMH) and monoclonal antibodies developed in our laboratory to a commercial firm, Immunotech Coulters, which has commercialised an ELISA for human anti-Mollerian hormone which can be used for the assay of AMH in human serum a...
Programme: FP4-BIOMED 2
Record Number: 26752
Last updated on: 2001-07-30
[REPORT SUMMARY] Novel strategies for detection of mutations in genes for basement membrane proteins
The molecular bases underlying the clinical observations that define the clinical variants of severe and mild junctional epidermolysis bullosa (JEB) have been clarified. The identification of new candidate genes in the clinical variants of JEB, and the identification of novel ...
Programme: FP4-BIOMED 2
Record Number: 26350
Last updated on: 2003-01-17
[REPORT SUMMARY] Identification of 9 human dynein heavy chain genes: partial sequences Chromosomal mapping of 6 of these dynein heavy chain genes
Dynein heavy chains are highly conserved from protozoa to human and by phylogenetic analysis, the evolutionary ancestry of these dynein heavy chain cDNA fragments was deduced. These dynein heavy chain cDNAs are highly transcribed in human tissues containing axonema such as tra...
Programme: FP4-BIOMED 2
Record Number: 25931
Last updated on: 2001-03-05
[REPORT SUMMARY] Virus Host interaction in the Hepatitis C: Analysis of the virusspecific T-Lymphocyte response as a basis for the development of a T-cell Vaccine.
The characterization of HCV specific cellular and humoral immune response in patients with self-limited acute hepatitis C led to the identification of immune mechanisms which are associated with viral clearance. This knowledge forms the basis for the development of protective ...
Programme: FP4-BIOMED 2
Record Number: 23259
Last updated on: 1999-10-28
[REPORT SUMMARY] Primary ciliary dyskinesia: A genome-wide linkage analysis reveals extensive Locus Heterogeneity
We have collected samples from 61 European and North American families with PCD. A genome-wide linkage search was performed in 31 multiplex families (169 individuals including 70 affecteds) using 188 evenly-spaced (19 cM average interval) polymorphic markers. Both parametric (...
Programme: FP4-BIOMED 2
Record Number: 25930
Last updated on: 2001-03-05
[REPORT SUMMARY] New technical approach to induce HLA class I restricted CTL response using recombinant vectors
Since HCV does not efficiently infect human cells in-vitro and primary infected hepatocytes cannot be used as stimulator/target cells for CTL analysis, the study of CTL activity has so far been severely hampered by the lack of systems to activate and expand CTL in-vitro, repro...
Programme: FP4-BIOMED 2
Record Number: 26767
Last updated on: 2001-07-30
List retrieved on: 2017-08-04
