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Final Report Summary - BROWSE (Bystanders, Residents, Operators and WorkerS Exposure models for plant protection products)
Executive Summary:The BROWSE project, supported by the EU 7th Framework Programme, has:• Reviewed, improved and extended the models currently used in the risk assessment of plant protection products (PPPs) to evaluate the exposure of operators, workers, residents and...
Record Number: 157865
Last updated on: 2015-03-25
KFKI general application of calibration techniques
The main activities of our institution directed to compile the scientific results achieved by other project partners and summarize the outcomes from the point of view of their possible applications. The main goal of the project was to improve the in vivo and bioassay monitorin...
Programme: FP5-EAECTP C
Record Number: 39503
Last updated on: 2010-03-08
Electronic database of information relating to the biokinetics of radionuclides after entry to the body by inhalation, ingestion or injection
The consortium collated and analysed information from the literature on experimental studies relating to the biokinetics of radioactive compounds. A wide range of radionuclides was covered, with emphasis on the actinides (e.g. uranium, plutonium), fission products (e.g. caesiu...
Programme: FP5-EAECTP C
Record Number: 44725
Last updated on: 2008-12-23
A bystander effect was found in co-cultured malignant trophoblast Jeg3 cells after 5 Gy X-rays using activation of p53 as endpoint
To study bystander effects, co-culture protocols were applied to examine the development of G2-arrest and the activation of p53 in a number of cell lines that were extensively characterized in term of their ability to establish gap juctional intercellular communication. A deta...
Programme: FP5-EAECTP C
Record Number: 44730
Last updated on: 2007-12-12
Cytogenetic experiments failed to detect clear evidence for a negative bystander response in human lymphocytes cultured with irradiated cells
Irradiated Go lymphocytes were fused to exponentially growing CHO cells and cultured for up to 30h. In the hybrid cells, lymphocyte PCCs were induced when CHO entered mitosis. Cells were harvested at various times after cell fusion using shake off and subsequently chromosome p...
Programme: FP5-EAECTP C
Record Number: 44729
Last updated on: 2007-12-12
No negative bystander effects were observed for human cells (HSF) exposed to either 4.5MeV alpha particles or 10MeV protons using a microbeam
In order to study the parameter of LET and cell type on the development of bystander effects using cell survival as endpoint, we carried out experiments with primary human skin fibroblasts (HSF2). Using 4.5MeV alpha particles (LET = 100keV/µm) we were unable to measure bystand...
Programme: FP5-EAECTP C
Record Number: 44728
Last updated on: 2007-12-12
Mouse models of telomerase overexpression
In the past, Maria Blasco and her team (partner CNIO) have shown that the telomerase reverse transcriptase component (Tert) may favour growth and survival independently of telomere length maintenance. They have generated two mouse models that over-express Tert under the kerati...
Programme: FP5-EAECTP C
Record Number: 44388
Last updated on: 2007-08-22
Roles of telomeric chromatin in malignant transformation
Recent evidence has associated telomere instability to oncogenesis but the mechanisms and the significance for human cancers remains elusive. To explore the ability of telomere dysfunction to promote neoplastic transformation in defined human cellular systems, Eric Gilson and ...
Programme: FP5-EAECTP C
Record Number: 44390
Last updated on: 2007-08-22
Radio-sensitivity, DNA repair and biology of telomeres in radiosensitive individuals
Fanconi anemia (FA) patients show accelerated telomere shortening. In order to get further insights in to the role of the FA pathway in telomere biology, Jordi Surralles and his team studied whether FANCD2, a key downstream factor in this pathway, binds to telomeres. They inve...
Programme: FP5-EAECTP C
Record Number: 44382
Last updated on: 2007-08-22
The Halosperm® kit to determine sperm DNA fragmentation
A simple and reliable procedure is now available, as a kit, to determine sperm DNA fragmentation. The integrity of sperm DNA is indeed being recognized as a new parameter of semen quality and a potential fertility predictor. However, it was not so far assessed as a routine par...
Programme: FP5-EAECTP C
Record Number: 44376
Last updated on: 2007-08-22
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List retrieved on: 2017-11-20
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