Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Periodic Report Summary 2 - EVOLRECOMBADAPT (Recombination in Adaptive Evolution)
The molecular mechanisms that shape genome function during adaptive evolution and species divergence are poorly understood. We aim to explore how meiotic recombination, an essential process of gametogenesis, varies across the genome and among diverging species and influences...
Programme: FP7-IDEAS-ERC
Record Number: 199366
Last updated on: 2017-06-21
Periodic Report Summary 2 - ENDOFUN (The endodermis - unraveling the function of an ancient barrier)
During the 30 months period of this project, we have published a first description of a mutant with a defect in the endodermal barrier (sgn3) (Pfister et al., eLife, 2014) and shown that this mutant has a whole suite of nutrient homeostatic defects, but that a main component...
Programme: FP7-IDEAS-ERC
Record Number: 199516
Last updated on: 2017-06-21
Periodic Report Summary 2 - PLURIMES (Pluripotent stem cell resources for mesodermal medicine)
Project Context and Objectives: Project Context The concept of PluriMes is to exploit the developmental programme of human pluripotent stem cell differentiation in order to capture mesodermal progenitor cells with therapeutic potency for diseases of skeletal muscle, bone and...
Programme: FP7-HEALTH
Record Number: 199533
Last updated on: 2017-06-21
Periodic Report Summary 2 - DYNGENOME (The Dynamics of Genome Processing)
We have advanced our understanding of, helicases, polymerases, and other molecular machines that help to read out and copy our genome. We have addressed three different phases of functioning for these machines: initiation, elongation, and termination. For example, we have...
Programme: FP7-IDEAS-ERC
Record Number: 199508
Last updated on: 2017-06-21
Periodic Report Summary 2 - ACQDIV (Acquisition processes in maximally diverse languages: Min(d)ing the ambient language)
The languages of the world are vastly different from each other and vary enormously in complexity. Notwithstanding, a child can learn any of them without difficulties. ACQDIV's main concern is why and how this is possible. Our leading hypothesis is that there is a small set of...
Programme: FP7-IDEAS-ERC
Record Number: 199517
Last updated on: 2017-06-21
Periodic Report Summary 2 - NIMO (Neural and Immune Orchestrators of Forebrain Wiring)
Brain functioning relies on complex circuits that begin to be established in the embryo by developmental programs which coordinate the assembly of millions of neurons. Such programs can be modulated by environmental signals, as illustrated by the fact that prenatal...
Programme: FP7-IDEAS-ERC
Record Number: 199507
Last updated on: 2017-06-21
Periodic Report Summary 2 - MYODYN (Myosins and the dynamics of intracellular membranes)
The goal of our project is to better understand the molecular mechanisms that underlie transport events occurring at the level of Golgi/Trans-Golgi network/endosomes in eukaryotic cells. Complex membrane trafficking, still largely unknown, takes place in this region of the...
Programme: FP7-IDEAS-ERC
Record Number: 199505
Last updated on: 2017-06-21
Periodic Report Summary 2 - BIO-PHONONICS (Advanced Microfluidics & Diagnostics using Acoustic Holograms – Bio-Phononics)
Synopsis of Outcomes: One important aim of this application has been the development of a new understanding of the physics and engineering of the interactions between sound and liquid interfaces within phononic structures. These phononic structures can be considered analogous...
Programme: FP7-IDEAS-ERC
Record Number: 199502
Last updated on: 2017-06-21
Periodic Report Summary 2 - ATECT (Advanced T-cell Engineered for Cancer Therapy)
Project Context and Objectives: Introduction: Chimeric Antigen Receptors (CARs), generated by fusing the antigen-binding region of a monoclonal antibody (mAb) to intracellular T-cell signalling domains1, hold the promise to revolutionise cancer treatment. Introduction of genes...
Programme: FP7-HEALTH
Record Number: 199544
Last updated on: 2017-06-21
Periodic Report Summary 2 - MYELOSHOCK (Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples)
Allergic shock (anaphylaxis) is a life-threatening reaction to allergens (food, drugs, pollens, venom, etc) occurring in individuals that produce particular antibodies against these allergens. Project MyeloSHOCK aims at unraveling the parameters that control anaphylaxis using...
Programme: FP7-IDEAS-ERC
Record Number: 199500
Last updated on: 2017-06-21
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List retrieved on: 2017-07-20
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