Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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We have demonstrated the efficacy of glucokinase gene transfection to muscle as a means of increasing glucose disposal in-vitro and in-vivo. Transfer of glucokinase gene in vivo restricted to leg muscle was shown to result in prolonged expression of the protein and enhanced gl...
Programme: FP4-BIOMED 2
Record Number: 26765
Last updated on: 2003-11-27
Injured nerve fibres in the spinal cord are unable to regenerate. Consequently, individuals who have sustained such injuries suffer from lifelong and seriously disabling loss of sensory and/or motor functions. The project has addressed the problem of overcoming spinal cord reg...
Programme: FP4-BIOMED 2
Record Number: 23186
Last updated on: 2003-01-17
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target autoantigen in MS. It is theref...
Programme: FP4-BIOMED 2
Record Number: 27107
Last updated on: 2003-01-17
Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recruit both an encephalitogenic T cell response and a demyelinating B cell response. It is therefore of interest to explore the genetic regulation of MOG induced experimenta...
Programme: FP4-BIOMED 2
Record Number: 27106
Last updated on: 2003-01-17
A new mouse model has been established that is useful as a model for multiple sclerosis. The mouse contains the following genes from humans; the human class II genes DRA and DRB, the human CD4 and a human T cell receptor (TCRA and TCRB) specific for a peptide derived from myel...
Programme: FP4-BIOMED 2
Record Number: 26347
Last updated on: 2003-01-17
By transfer of a curative transgene, we have achieved the full phenotypic reversion of primary keratinocytes of patients with a mild form of junctional epidermolysis bullosa (JEB) associated with genetic point mutations in the laminin beta3 gene. These findings confirm the fea...
Programme: FP4-BIOMED 2
Record Number: 26351
Last updated on: 2003-01-17
The molecular bases underlying the clinical observations that define the clinical variants of severe and mild junctional epidermolysis bullosa (JEB) have been clarified. The identification of new candidate genes in the clinical variants of JEB, and the identification of novel ...
Programme: FP4-BIOMED 2
Record Number: 26350
Last updated on: 2003-01-17
Summary: We have raised a polyclonal antibody recognizing human deoxycytide kinase (dCK) protein. The antibody is highly specific for dCK and has been tested for suitability in different applications. The antibody detects dCK in western blots, immunoprecipitation and in situ i...
Programme: FP4-BIOMED 2
Record Number: 23744
Last updated on: 2003-01-17
We have developed a parallel multiple read-out scheme for monitoring on-line hybridization reactions in real time between surface-attached DNA oligonucleotides and complementary strands (oligonucleotides or DNA) from solution by using our earlier introduced surface-plasmon fie...
Programme: FP4-BIOMED 2
Record Number: 27105
Last updated on: 2003-01-17
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recr...
Programme: FP4-BIOMED 2
Record Number: 27121
Last updated on: 2003-01-17
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List retrieved on: 2017-07-24
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