Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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We have demonstrated the efficacy of glucokinase gene transfection to muscle as a means of increasing glucose disposal in-vitro and in-vivo. Transfer of glucokinase gene in vivo restricted to leg muscle was shown to result in prolonged expression of the protein and enhanced gl...
Programme: FP4-BIOMED 2
Record Number: 26765
Last updated on: 2003-11-27
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recr...
Programme: FP4-BIOMED 2
Record Number: 27121
Last updated on: 2003-01-17
We have developed a very sensitive microassay, which allows to accurately measure low amounts of steroids in small tissue samples. It is based on the extraction of steroids from tissue, their separation by gas chromatography (GC) and their identification by mass spectrometry (...
Programme: FP4-BIOMED 2
Record Number: 27109
Last updated on: 2003-01-17
GABAB receptors are proteins that can be found on the surface of nerve cells (i.e. neurones), and upon which GABA (a substance that mediates the transfer of electrical signals between neurons) interacts to produce a number of physiological effects. Our result can be broken dow...
Programme: FP4-BIOMED 2
Record Number: 27108
Last updated on: 2003-01-17
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target autoantigen in MS. It is theref...
Programme: FP4-BIOMED 2
Record Number: 27107
Last updated on: 2003-01-17
We have developed a parallel multiple read-out scheme for monitoring on-line hybridization reactions in real time between surface-attached DNA oligonucleotides and complementary strands (oligonucleotides or DNA) from solution by using our earlier introduced surface-plasmon fie...
Programme: FP4-BIOMED 2
Record Number: 27105
Last updated on: 2003-01-17
Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recruit both an encephalitogenic T cell response and a demyelinating B cell response. It is therefore of interest to explore the genetic regulation of MOG induced experimenta...
Programme: FP4-BIOMED 2
Record Number: 27106
Last updated on: 2003-01-17
We have genetically engineered V79 cells (Chinese hamster lung fibroblasts) by cDNA encoding the rat liver UDP-glucuronosyltransferase (UGT) isoforms, UGT1A6 and UGT2B1. These proteins are involved in the glucuronidation of toxic substances, such as phenols (carcinogens, pesti...
Programme: FP4-BIOMED 2
Record Number: 26754
Last updated on: 2003-01-17
By transfer of a curative transgene, we have achieved the full phenotypic reversion of primary keratinocytes of patients with a mild form of junctional epidermolysis bullosa (JEB) associated with genetic point mutations in the laminin beta3 gene. These findings confirm the fea...
Programme: FP4-BIOMED 2
Record Number: 26351
Last updated on: 2003-01-17
The molecular bases underlying the clinical observations that define the clinical variants of severe and mild junctional epidermolysis bullosa (JEB) have been clarified. The identification of new candidate genes in the clinical variants of JEB, and the identification of novel ...
Programme: FP4-BIOMED 2
Record Number: 26350
Last updated on: 2003-01-17
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List retrieved on: 2017-12-11
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