Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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We have demonstrated the efficacy of glucokinase gene transfection to muscle as a means of increasing glucose disposal in-vitro and in-vivo. Transfer of glucokinase gene in vivo restricted to leg muscle was shown to result in prolonged expression of the protein and enhanced gl...
Programme: FP4-BIOMED 2
Record Number: 26765
Last updated on: 2003-11-27
Non-viral therapy would in principle be preferable over viral therapy especially in underdeveloped countries simply because non-viral components are easier and cheaper to synthesize, store and transport. However they are a number of problems with this approach, including effic...
Programme: FP4-BIOMED 2
Record Number: 25937
Last updated on: 2003-01-17
Injured nerve fibres in the spinal cord are unable to regenerate. Consequently, individuals who have sustained such injuries suffer from lifelong and seriously disabling loss of sensory and/or motor functions. The project has addressed the problem of overcoming spinal cord reg...
Programme: FP4-BIOMED 2
Record Number: 23186
Last updated on: 2003-01-17
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recr...
Programme: FP4-BIOMED 2
Record Number: 27121
Last updated on: 2003-01-17
We have developed a very sensitive microassay, which allows to accurately measure low amounts of steroids in small tissue samples. It is based on the extraction of steroids from tissue, their separation by gas chromatography (GC) and their identification by mass spectrometry (...
Programme: FP4-BIOMED 2
Record Number: 27109
Last updated on: 2003-01-17
GABAB receptors are proteins that can be found on the surface of nerve cells (i.e. neurones), and upon which GABA (a substance that mediates the transfer of electrical signals between neurons) interacts to produce a number of physiological effects. Our result can be broken dow...
Programme: FP4-BIOMED 2
Record Number: 27108
Last updated on: 2003-01-17
Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recruit both an encephalitogenic T cell response and a demyelinating B cell response. It is therefore of interest to explore the genetic regulation of MOG induced experimenta...
Programme: FP4-BIOMED 2
Record Number: 27106
Last updated on: 2003-01-17
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target autoantigen in MS. It is theref...
Programme: FP4-BIOMED 2
Record Number: 27107
Last updated on: 2003-01-17
We have developed a parallel multiple read-out scheme for monitoring on-line hybridization reactions in real time between surface-attached DNA oligonucleotides and complementary strands (oligonucleotides or DNA) from solution by using our earlier introduced surface-plasmon fie...
Programme: FP4-BIOMED 2
Record Number: 27105
Last updated on: 2003-01-17
We have genetically engineered V79 cells (Chinese hamster lung fibroblasts) by cDNA encoding the rat liver UDP-glucuronosyltransferase (UGT) isoforms, UGT1A6 and UGT2B1. These proteins are involved in the glucuronidation of toxic substances, such as phenols (carcinogens, pesti...
Programme: FP4-BIOMED 2
Record Number: 26754
Last updated on: 2003-01-17
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List retrieved on: 2017-03-30
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