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Le informazioni sui progetti di Orizzonte 2020 e ora anche le relative sintesi delle relazioni sono disponibili su CORDIS. Tutti i progetti H2020 possono essere scaricati dal Portale Open Data dell'UE .

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Roles of telomeric chromatin in malignant transformation
Recent evidence has associated telomere instability to oncogenesis but the mechanisms and the significance for human cancers remains elusive. To explore the ability of telomere dysfunction to promote neoplastic transformation in defined human cellular systems, Eric Gilson and ...
Programme: FP5-EAECTP C
Record Number: 44390
Last updated on: 2007-08-22
Ligase III: a role in a new NHEJ pathway to repair DNA double strand breaks?
Chromosome fusions are observed with high frequency in cells with defects in components of the standard pathway of DNA double strand break repair which suggests the operation of an alternative repair pathway that is capable of joining together eroded telomeric sequences when t...
Programme: FP5-EAECTP C
Record Number: 44377
Last updated on: 2007-08-22
Radio-sensitivity, DNA repair and biology of telomeres in radiosensitive individuals
Fanconi anemia (FA) patients show accelerated telomere shortening. In order to get further insights in to the role of the FA pathway in telomere biology, Jordi Surralles and his team studied whether FANCD2, a key downstream factor in this pathway, binds to telomeres. They inve...
Programme: FP5-EAECTP C
Record Number: 44382
Last updated on: 2007-08-22
Link between telomere maintenance & DNA damage response mechanisms, and their role of individual radio-sensitivity. Insights on action of BRCA1 gene
Telomeres are physical ends of chromosomes responsible for chromosomal end protection. There is a strong inter-dependence between telomere maintenance and cellular mechanisms that regulate DNA damage response. At least 17 mammalian genes involved in DNA damage response have, s...
Programme: FP5-EAECTP C
Record Number: 44378
Last updated on: 2007-08-22
Double strand break repair functions and gene amplification
It is known that DNA-PKcs is a key protein for the repair of DSBs through the NHEJ pathway and that DSBs can initiate gene amplification. The results obtained by Elena Giulotto and Chiara Mondello indicate that in human cells an impairment in DNA-PKcs function increases the pr...
Programme: FP5-EAECTP C
Record Number: 44379
Last updated on: 2007-08-22
Telomere and whole genome tri-dimensional reconstruction of inter-phase nuclei architecture in response to ionising radiation
Jordi Surralles' objective was to study the architecture of the inter-phase nuclei from the telomere perspective and it response to ionising radiation. He found that telomeres have a defined 3D distribution pattern inside the interphase nucleus that is independent of histone H...
Programme: FP5-EAECTP C
Record Number: 44383
Last updated on: 2007-08-22
Mouse models of telomerase overexpression
[SINTESI DELLA RELAZIONE] Mouse models of telomerase overexpression
In the past, Maria Blasco and her team (partner CNIO) have shown that the telomerase reverse transcriptase component (Tert) may favour growth and survival independently of telomere length maintenance. They have generated two mouse models that over-express Tert under the kerati...
Programme: FP5-EAECTP C
Record Number: 44388
Last updated on: 2007-08-22
Erforschung der Auswirkungen von Bestrahlung
Die Abschätzung des strahlungsinduzierten Krebsrisikos beim Menschen ist nicht einfach.
Programme: FP5-EAECTP C
Record Number: 84652
Last updated on: 2008-12-15
Available languages: DE, EN, ES, FR, IT, PL
Understanding the effect of radiation
The cancer risk induced by radiation exposure in humans is still not easy to calculate.
Programme: FP5-EAECTP C
Record Number: 84652
Last updated on: 2008-12-15
Available languages: DE, EN, ES, FR, IT, PL
Comprender el efecto de la radiación
El riesgo de cáncer que implica la exposición de los humanos a la radiación todavía no es sencillo de calcular.
Programme: FP5-EAECTP C
Record Number: 84652
Last updated on: 2008-12-15
Available languages: DE, EN, ES, FR, IT, PL
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List retrieved on: 2017-07-28