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FP7

Periodic Report - MDDANEURODEV (Molecular coding and subset specification of dopamine neurons generating the meso-limbic and nigro-striatal system)

Project ID: 222999
Funded under: FP7-HEALTH

Abstract

This is the periodic report of the MDDANEURODEV project, which was funded by the European Community and aimed at identifying molecular and physiological mechanisms of the development and maintenance of mesodiencephalic dopaminergic (mdDA) neurons. The document summarises the project objectives and then focuses on the three work packages (WPs) that are undertaken and presents their principal results. WP1 is concerned with the ventricular zone programming and early specification of the mdDA neuronal phenotype. WP2 examines mechanisms of neurons' migration and guidance. On the other hand, WP3 is concerned with genetic programming, terminal differentiation and maintenance. The report also provides an overview of MDDANEURODEV success and closes with a reference to the project anticipated results.

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