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FP7

Final Report - PHAGOCYTOSIS (Molecular mechanisms underlying the link between the vitamin K-dependent proteins, Gas6 and protein-S, and phagocytosis of apoptotic cells during cell differentiation ¿)

Project ID: 220892
Funded under: FP7-PEOPLE

Abstract

This is the final report for 'Molecular mechanisms underlying the link between the vitamin K-dependent proteins, Gas6 and protein-S, and phagocytosis of apoptotic cells during cell differentiation' (Phagocytosis). The major aims of the Phagocytosis was to assess to what extent substrate binding, ingestion and degradation stages during non-professional phagocytosis may be tissue-specific, how the phagocytosis process may be regulated by vitamin K-dependent proteins and which are the signalling pathways that regulate this process.

The study established study that substrate binding and ingestion phagocytosis stages occur similarly whether Sertoli cell cultures are exposed to apoptotic substrates derived from the testis or the retina. The report also shows that the nature of phagocytosis substrates is a major factor that should be taken into account for the study of phagocytosis machinery by non-professional phagocytes.

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Related information

Record Number: 10786 / Last updated on: 2011-03-29
Category: PROJ