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FP6

Final Report - UNIVERSAL VACCINE (Novel antigen-adjuvant vehicle as an effective influenza vaccine)

Project ID: 17749
Funded under: FP6-SME

Abstract

UNIVERSAL VACCINE was a European funded project within the Sixth Framework Programme (FP6) whose overall objective was to integrate the scientific excellence and technologies of Small and medium-sized enterprises (SMEs) with these of Research and technological development (RTD) performers with the aim of developing a powerful, safe and easily-administered mucosal vaccine for humans providing lifelong protection against influenza.

The end results supported the hypothesis that a universal influenza vaccine could be developed based on the rationale of the joint research and development collaboration. Several vaccine candidates were developed providing protection in a mouse challenge model and demonstrated adequate and relevant immunologic responses. By refining the composition of the various vaccine parts, an optimal candidate vaccine product protected by novel Iron regulatory proteins (IRP) was developed. Concomitantly, important knowledge regarding the involved immune mechanisms in host protection against viral infection was generated.

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