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FP7

Final Report - GASMALARIA (Crosstalk between nitric and carbon monoxide in suppressing the pathogenesis of cerebral Malaria)

Project ID: 220152
Funded under: FP7-PEOPLE

Abstract

The central hypothesis to be tested under this project was that the gasotransmitters nitric oxide (NO) and carbon monoxide (CO) interact functionally to modulate the pathogenesis of cerebral malaria. Research into the mechanisms involved in severe sepsis has concluded that free haem - a component of haemoglobin containing iron and other atoms - plays a key role in the progression of the disease. The research also unveiled the therapeutic potential of a naturally occurring haem-scavenging molecule. The findings were published in the journal 'Science Translational Medicine' on 29 September 2010.

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