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FP7

Periodic Report - FAST-XDR-DETECT (Development of a two-approach plate system for the fast and simultaneous detection of MDR and XDR M. tuberculosis)

Project ID: 201690
Funded under: FP7-HEALTH

Abstract

Tuberculosis (TB) remains as a big killer among infectious diseases with 1.3 million deaths attributed to the disease in 2007. The HIV/AIDS pandemic and the emergence of drug resistance are signalled as the two main reasons for the deterioration of the TB situation worldwide. HIV/TB co-infection constitutes a deadly combination each one accelerating the development of the other disease. Approximately one third of the HIV/AIDS patients worldwide are co-infected with TB and in 2007 there were an additional 456 000 deaths among TB patients co-infected with HIV. The overall objective of this project was to develop a two-approach system for the simultaneous detection of MDR- and XDR-TB in M. tuberculosis isolates and directly on sputum samples.

The final report cover the outcomes of the project which include fast and improved assays for detection of MDRand XDR-TB both as an indirect method in M. tuberculosis isolates, as well as directly in sputum samples. This project will go a step further by developing and testing a double approach for the simultaneous detection of MDR-TB and XDR-TB in clinical isolates of M. tuberculosis in a first phase, and directly on sputum specimens once the fast phenotypic colorimetric assay and the molecular test are completely developed. Very few of the available tests have been designed for or applied in sputum samples. The project will also contribute to the current knowledge of the mechanisms of M. tuberculosis resistance to second-line drugs.

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Related information

Record Number: 11334 / Last updated on: 2014-07-04
Category: PROJ
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