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FP7

Final Report - AMIDIM (Effects of antibiotic administration on the composition of the human intestinal microbiota … and the development of antibiotic-associated diarrhoea)

Project ID: 220815
Funded under: FP7-PEOPLE

Abstract

The project AMIDIM was initiated to address the impact of long-term antibiotic treatment on human health by establishing effects on the composition of the human gut microbiota, on the spread of bacterial antibiotic resistance genes, and on the colonisation by virulent drug resistant opportunistic pathogenic bacteria.

The project was initiated with the hypothesis that extensive tetracycline therapy could have a significant impact on the long-term composition of the gut microbiota, with detrimental consequences for gut health.

Their report concludes that since there was no increase in the carriage of C. difficile, and the changes in the composition of the gut microbiota and in the carriage of resistance genes were transient, we can conclude that, based on our results, long-term treatment of healthy individuals with tetracycline derivatives does not have a permanent detrimental effect on gut health.

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