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FP7

Final Report - 'RIBOSOME MM' (A synthetic molecular machine capable of complex task performance: processive sequence-selective synthesis)

Project ID: 235491
Funded under: FP7-PEOPLE

Abstract

The aim of the 'RIBOSOME MM project was to synthesise and demonstrate the successful operation of one of the first synthetic molecular machines capable of performing a complex task at the molecular level. The target was to mimic translation, the process through which protein is synthesised on the mRNA template in the ribosome.

To achieve this ambitious task (in a very basic form) through the action of a wholly artificial molecular machine system, the project partners proposed to utilise a rotaxane in which the macrocycle component acts as both a catalyst and a molecular transporter, abstracting bulky aromatic amino acid substituents from a sequence-specific thread and transporting them in turn to the next amino acid fragment before mediating the formation of a new amide bond between them.

The report features a cartoon depiction of a rotaxane-based molecular machine capable of sequence specific peptide synthesis.

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Related information

Record Number: 11358 / Last updated on: 2011-08-02
Category: PROJ
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