Community Research and Development Information Service - CORDIS


Final Report - BIORESS (Bioactive resorbable scaffolds for drug delivery in bone tissue engineering)

Project ID: 210362
Funded under: FP7-PEOPLE


Bone replacements are frequently required to substitute damaged tissue due to any trauma, disease or surgery. The current therapies for bone grafts: autografts (taken directly from the patient), allografts (taken from a cadaver donor) or xenograft (taken from animals), are limited in availability and can be associated with patient morbidity or with the risk of inducing transmissible diseases.

Due to the numerous restrictions that biologic grafts present, the development of synthetic materials and their employment in tissue engineering implants is continuously increased. The development of synthetic bone substitutes as drug delivery systems has been one of the most important topics in the bone tissue engineering field.

The aim of the BIORESS project was the development, characterisation and in vitro experimentation of novel macroporous scaffolds with highly interconnected porosity and controlled biodegradability for drug delivery in bone tissue engineering. The report concludes that during this project, a new bioactive and bioresorbable phosphate glass was produced and characterised.

This glass was then utilised to produce bioactive and bioresorbable scaffold with highly porous structure and interconnected porosity for bone tissue engineering. It has shown a stimulatory effect in promoting osteogenesis. Due to its high porosity and interconnectivity, the scaffolds can be used as drugs carriers for drug delivery systems.

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