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  • Final Report - CANNABISTARG (Regulation of normal and pathological activity of cortical networks by cannabinoids: focus on direct modulation of inhibitory GABAA and glycine receptors)
FP7

Final Report - CANNABISTARG (Regulation of normal and pathological activity of cortical networks by cannabinoids: focus on direct modulation of inhibitory GABAA and glycine receptors)

Project ID: 237781
Funded under: FP7-PEOPLE

Abstract

Epilepsy is one of the most common neurological disorders affecting 2 % of the world's population, in which normal brain function is disrupted as a consequence of intensive and synchronous burst activity from neuron assemblies. At present approximately 30 % of epileptics are not adequately controlled with conventional drugs due to development of tolerance and pharmacoresistance, therefore justifying the search for new antiepileptic targets.

The project hypothesised that direct modulation of inhibitory synaptic transmission by cannabinoids might have high impact on initiation and development of the epileptoform activity and may provide effective tools for controlling the network function. The report includes and image.

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Related information

Record Number: 11368 / Last updated on: 2011-08-02
Category: PROJ