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Final Report - ACTIVOXY (Oxygen activation in ribonucleotide reductase and multicopper oxidases proteins)

Project ID: 235237
Funded under: FP7-PEOPLE


Through evolution, nature has engineered diverse molecules programmed to be the active components in 'key metabolic paths' of the oxygen metabolism in life. These molecules often contain copper and / or iron metal ions as operational engines; here, processes such as O2 binding and transport, reduction of O2 to peroxide coupled with oxidation of various types of substrates, or O2 detoxification take place. Understanding the functional factors that regulate the red-ox chemistry and hence the reactivity towards oxygen of the protein-caged metal ion(s) and or molecular cofactors were the research objectives of Dr Giorgio Zoppellaro's biomedical / biophysical projects.

Overall, according to the report, the research achievements attained under the IEF Marie Curie framework allowed Dr Giorgio Zoppellaro to strengthen his expertise in a trans-disciplinary fields (chemistry / biology / biophysics / medicine) as evidenced by the number of peer reviewed publications and presentations of the scientific results in International conferences. In addition to the research work pursued, the fellow was actively involved in mentoring activities.

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