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FP7

Final Report - WNT IN THE INTESTINE (Wnt signalling in colorectal carcinogenesis and intestinal homeostasis)

Project ID: 235848
Funded under: FP7-PEOPLE

Abstract

The intestinal epithelium is a highly self-renewing tissue, which is replenished by multipotent stem cells. Deregulation of normal intestinal homeostasis often results in malignant transformation. Colorectal carcinoma is one of the most common cancers in western world. Inactivating mutations of the adenomatous polyposis coli (APC) gene is key for colorectal cancer; up to 80 % of sporadic colorectal cancers have APC mutations.

Their periodic report includes four images:
1) schematic model summarising results; 2) Src overexpression is sufficient to drive hyperplasia in the adult Drosophila mid-gut;
3) Src is required for intestinal regeneration and APC-driven tumourgenesis in the mouse intestine; and
4) dual role of Drosophila TNF signalling as a tumour promoter and tumour suppressor.

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