Community Research and Development Information Service - CORDIS


Final Report - MYCOMANCY (Transcriptional regulation and cellular localization of mycobacterial cell cycle proteins during dormancy)

Project ID: 37566


This is the final report for the MYCOMANCY project the aim of which was to study the relation between the cell cycle and dormancy development in Mycobacterium tuberculosis (Mtb). During the course of this project the project produced and purified 14 different antibody against the Mtb cell division proteins. Eight of them were shown to be of a suitable for immunolocalisation and the respective proteins were already localised in actively growing Mtb. Further studies on the proteins encoded by these genes will increase our knowledge of the mechanism used by mycobacteria to survive in low oxygen environment and represent good candidate for the development of drugs active against dormant bacteria.

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