Community Research and Development Information Service - CORDIS

FP6

Final Report - TB-MACS (Identification and characterization of Mycobacterium tuberculosis virulence genes involved in macrophage parasitism)

Project ID: 37732
Funded under: FP6-LIFESCIHEALTH

Abstract

This is the final report of the TB-MACS project which proposed to use innovative genetic screens to reveal the genetic and mechanistic basis of this characteristic. Specifically, TB-MACS utilised a microarray based screening of an M. tuberculosis mutant library in two separate selections to identify mutants that are unable to inhibit phagosome acidification and / or unable to inhibit fusion of the phagosome with hydrolytic lysosomes.

Information derived from the project will help identify novel drug targets for consideration in the development of chemotherapy strategies. Mycobacterial mutants generated during TBMACS may form the basis of novel attenuated vaccine strains.

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Related information

Record Number: 12234 / Last updated on: 2011-04-14
Category: PROJ